Cardizem

Systemic and coronary arteries are influenced by movement of calcium across cell membranes of vascular smooth muscle. The contractions of cardiac and vascular smooth muscle depend on movement of extracellular calcium ions into these walls through specific ion channels. Calcium channel blockers, such as amlodipine (Norvasc), diltiazem (Cardizem), nicardipine (Cardene), nifedipine (Procardia), and verapamil (Calan), inhibit die movement of calcium ions across cell membranes. This results in less calcium available for the transmission of nerve impulses (Fig. 41-1). This drug action of the calcium channel blockers (also known as slow channel blockers) has several effects on die heart, including an effect on die smooth muscle of arteries and arterioles. These drug dilate coronary arteries and arterioles, which in turn deliver more oxygen to cardiac muscle. Dilation of peripheral arteries reduces die workload of die heart. The end effect of these drug is the same as that of die nitrates. 

Calcium channel blocking drug s—for example, amlodipine (Norvasc) and diltiazem (Cardizem)... 

Isoptin SR, Verelan) 180-480 Amlodipine (Norvasc) 5-10 Nifedipine long-acting (Adalat CC, Procardia XL) 30-90 Diltiazem sustained-release (Cardizem SR) 180-360 Diabetes... 

Diltiazem extended-release (Cardizem LA) 120-540 1 (morning or evening)... 

Carditoxin, molecular formula and structure, 5 180t Cardizem, molecular formula and structure, 5 97t, 118t Cardoxin, molecular formula and structure, 5 18 It Cards... 

The brand-name drug products included in the study represent some of the largest drug products as measured by annual sales. They include blockbuster drugs such as Capoten, Cardizem CD, Cipro, Claritin, Lupron, Neurontin, Paxil, Pepcid, Pravachol, Prilosec, Procardia XL, Prozac, Vasotec, Xanax, Zantac, Zocor, Zoloft, and... 

Two district court decisions have examined the use of brand payment provisions in the settlement agreements involving Cardizem CD and Hytrin. Both courts have foimd the agreements to be per se restraints of trade imder Section 1 of the Sherman Antitmst Act. In re Cardizem CD Antitrust Litigation, 105 F.Supp.2d 618, 684 (E.D. Mich. 2000) and 105 F.Supp.2d 618, 622 (E.D. Mich. 2000) In re Terazosin Hydrochloride Antitrust Litigation, 164 F.Supp.2d 1340, 1342 (S.D. FI. 2000). 

Diltiazem Hydrochloride Cardizem SR 60, 90, 120 mg extended-release capsirles... 

It is used for stable and nonstable angina pectoris (including after myocardial infarctions) as well as in arterial hypertension. Universally accepted synonyms of this dmg are cardizem, dilacor, tiazac, iproventaril, and others. 

In newborns, because of the presence of benzyl alcohol Cardizem Lyo-Ject Syringe only). 

Cardizem CD, Cardizem SR, Cartia XT, Dilacor XR, Diltia XT, Taztia XT, Tiamate, Tiazac)... 

The antiarrhythmic actions and uses of diltiazem (Cardizem see Chapter 19) are similar to those of verapamil. Diltiazem is effective in controlling the ventricular rate in patients with atrial flutter or atrial fibrillation. The pharmacology of diltiazem is discussed in detail in Chapter 19. 

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