Carden cardizem

Systemic and coronary arteries are influenced by movement of calcium across cell membranes of vascular smooth muscle. The contractions of cardiac and vascular smooth muscle depend on movement of extracellular calcium ions into these walls through specific ion channels. Calcium channel blockers, such as amlodipine (Norvasc), diltiazem (Cardizem), nicardipine (Cardene), nifedipine (Procardia), and verapamil (Calan), inhibit die movement of calcium ions across cell membranes. This results in less calcium available for the transmission of nerve impulses (Fig. 41-1). This drug action of the calcium channel blockers (also known as slow channel blockers) has several effects on die heart, including an effect on die smooth muscle of arteries and arterioles. These drug dilate coronary arteries and arterioles, which in turn deliver more oxygen to cardiac muscle. Dilation of peripheral arteries reduces die workload of die heart. The end effect of these drug is the same as that of die nitrates. 

Amlodipine (Norvasc) Bepridil (Vascor) Diltiazem (Cardizem) Felodipine (Plendil) Isradipine (DynaCirc) Nicardipine (Cardene) Nifedipine (Adalat, Procardia) Nimodipine (Nimotop) Verapamil (Calan, Isoptin)... 

Calcium channel blockers, including diltiazem (Cardizem SR, Dilacor XR, Tiazac), nicardipine (Cardene), amlodipine (Norvasc), felodipine (Plendil), and enalapril maleate-felodipine ER (Lexxel). 

Cardizem, Cardizem CD, Cardizem SR, Discor XR, Verelan, Calan SR, Isoptin SR Plendil Cardene SR... 

Representative Compounds Amlodipine Bepridil Diltiazem Felodipine Isradipine Nicardipine Nifedipine Nimodipine Verapamil Chemical Abstracts Service Registry Numbers Norvasc (CAS 88150-42-9) Vascor (CAS 74764-40-2) Cardizem (CAS 42399-417) Plendil (CAS 72509-76-3) DynaCirc (CAS 75695-93-1) Cardene (CAS 55985-32-5) Procardia... 

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