Cardiovascular disease overview

The above scientific information on rice bran phytochemicals indicates that a multitude of mechanisms are operating at the cellular level to bring about specific health effects. Several health benefits of rice bran appear to be the result of the synergistic function of the many phytochemicals, antioxidants, vitamins and minerals which operates through a specific immune response. Their role in the biochemical mechanisms at the cellular level which result in major health effects is shown in Fig. 17.1. A short overview summarizing the effect of the various phytochemicals on major health issues such as cancer, immune function, cardiovascular disease, diabetes, altered liver function and gastrointestinal and colon disease will be given below. 

Thus far, the discussion relating to the medical uses of monoclonals has focused exclusively upon cancer. Monoclonal antibodies (and their derivatives), however, have a far broader potential therapeutic application. Actual/potential additional uses include detection and treatment of cardiovascular disease, infectious agents, and various additional medical conditions. These are overviewed in Table 10.8. Specific examples of products already approved are provided in Table 10.4. 

Lowe GD, The relationship between infection, inflammation, and cardiovascular disease an overview. Ann Periodontol 2001 6(1) 1-8. 

WT Friedewald. Overview of recent clinical and methodological advances from clinical trials of cardiovascular disease. Control Clin Trials 3 259-270, 1982. 

LangsjoenPH and LangsjoenAM (1999) Overview of the use of CoQlO in cardiovascular disease. Biofactors9, 273-84. 

Hu FB. Plant-based foods and prevention of cardiovascular disease an overview. Am J Clin Nutr. 2003 78 5448-55IS. 

Blom HJ. Smulders Y. Overview of homocysteine and folate metabohsm. With special references to cardiovascular disease and neural tube defects. J Inherit Metab Dis. 2011 34(1) 75-81. 

Berry, SEE. Triacylglycerol structure and interesterification of palmitic and stearic acid-rich fats an overview and implications for cardiovascular disease. Nutr Res Rev, 2009 22 3-17. 

Perry HM Jr, Perry EF, Erlanger MW (1980) Possible influence of heavy metals in cardiovascular disease Introduction and overview. J. Environ. Pathol. Toxicol. 4 195-203... 

In Chapter 1, John Lowe details The Role of Medicinal Chemistry in Drug Discovery in the twenty first century. The overview should prove invaluable to novice medicinal chemists and process chemists who are interested in appreciating what medicinal chemists do. In Chapter 2, Neal Anderson summarizes his experience in process chemistry. The perspectives provide a great insight for medicinal chemists who are not familiar with what process chemistry entails. Their contributions afford a big picture of both medicinal chemistry and process chemistry, where most of the readers are employed. Following two introductory chapters, the remainder of the book is divided into three major therapeutic areas I. Cancer and Infectious Diseases (five chapters) II. Cardiovascular and Metabolic Diseases (six chapters) and III. Central Nervous System Diseases (four chapters). 

FIGURE 1 Overview of metabolomics approaches in the discovery of cardiovascular and renal disease biomarkers. 

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