Cardiovascular consequences

Grosser T, Fries S, Fitzgerald GA (2006) Biological basis for the cardiovascular consequences of COX-2 inhibition therapeutic challenges and opportunities. J Clin Invest 116 4-15... 

N. E. Buss, A. G. Renwick, K. M. Donaldson, C. F. George, The Metabolism of Cycla-mate to Cyclohexylamine and Its Cardiovascular Consequences in Human Volunteers , Toxicol. Appl. Pharmacol. 1992, 115, 199-209. 

The lack of evidence of severe mental or emotional disturbances, even In volunteers who were observed to experience intense and persistent cardiovascular effects, is noteworthy. Although DMHP acetate elicits far greater cardiovascular consequences than other canna-binoids, It appears to Induce less severe mental impairment. It Is possible that careful screening and a supportive test milieu tend to minimize the occurrence of adverse mental effects. 

Other nonpsychotropic drugs are also substrates (Fig. 6—17) or inhibitors of 3A4 (Fig. 6—18). It is important to understand the consequences of concomitant administration of psychotropic drugs that are either substrates or inhibitors of 3A4 with nonpsychotropic drugs that are also either substrates or inhibitors of 3A4. Notably, some 3A4 substrates such as cisapride, terfenidine, and astemazole must be metabolized, or else toxic levels of the drug can accumulate, with cardiovascular consequences such as prolonged QT interval and sudden death. Thus, they cannot be... 

Okerberg, K., and Hamilton, D. A. 2003. Cardiovascular consequences of obesity. Curr. Womens Health Rep. 3 110-115. 

Both type I and II pyrethroids cause marked adrenal activation in rats, probably by a direct activation of norepinephrine release. The type II pyrethroid deltamethrin causes increased corticosteroid secretion, and even moderate pyrethroid poisoning occurs against a background of profound adrenal activation - with corresponding behavioral and cardiovascular consequences. With only type II pyrethroids there is also a direct increase in cardiac contractility, although blood pressure remains well controlled. 

Yang R, Barouch LA (2007) Leptin signaling and obesity cardiovascular consequences. Circ Res 101 545-559... 

Malfunction of the thyroid gland results in serious metabolic disorders, with cardiovascular consequences. The thyroid gland secretes thyroxin, an iodine derivative of tyrosine. The thyroid gland therefore concentrates iodine, and administration of iodine-123, which is a y-emitter, will allow direct observation of the radionuclides distribution in the gland, using radiation detection apparatus. Uneven distribution will reveal the presence and possibly the type of disorder. 

Bataillard, A., F. Sannajust, D. Yoccoz, G. Blanche , H. Sentenac-Roumanou, and J. Sassard. 1990. Cardiovascular consequences of organophosphorus poisoning and of antidotes in conscious unrestrained rats. Pharmacol. Toxicol. (Copenhagen) 67(1) 27-35 cited in Chem. Abstr. CA 113(19) 167157v. 

Sidney S Cardiovascular consequences of marijuana use. J Clin Pharmacol 2002 42(11 Suppi) 64-70. [PMID 12412838] (Marijuana use increases heart rate and biood pressure, and shortens the time to onset of chest pain in patients with angina.)... 

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