Cardioactive properties

Thus, compound SC 4453 (1), a pyridazine analogue of digoxin studied in Belgium, has been shown to have cardioactive properties similar to those of the natural cardiac glycoside [3], 17 -(4-Pyridazinyl)androstane deriva-... 

Dowdy EG, Holland WC, Yamanaka I, Kaya K. Cardioactive properties of d-tubocurarine with and without preservatives. Anesthesiology 1971 34 256-260. 

Broom has cardioactive, diuretic, peripheral vasoconstrictor, and antihemorrhagic properties. It has been used for cardiac dropsy, myocardial weakness, tachycardia, profuse menstruation, and specifically for functional palpitation with lowered blood pressure. Broom is also reported to possess emetic and cathartic properties. 

Cola is believed to have central nervous system (CNS)-stimulant, thymoleptic, antidepressant, diuretic, cardioactive, and antidiarrheal properties. It is used to treat depressive states, melancholy, atony, exhaustion, dysentery, atonic diarrhea, anorexia, migraine, and particularly depressive states associated with general muscular weakness. 

Squill possesses expectorant, cathartic, emetic, cardioactive, and diuretic properties. Traditionally, it has been used for chronic bronchitis, asthma with bronchitis, whooping cough, and specifically for chronic bronchitis with scanty sputum. 

Broom 2. Ginkgo biloba 3. Scopolia 4. Yohimbine 1. TCAs (e.g. amitriptyline, nortriptyline, clomipramine) 2. SSRIs (e.g. fluvoxamine fluoxetine, paroxetine) 3. Venlafaxine 4. Trazodone May develop cardiac arrhythmias and side-effects such as dryness of the mouth, retention of urine and tachycardia, t sedation Broom contains cardioactive alkalamines such as sparteine Inhibits metabolizing enzymes Anticholinergic properties (hyoscine present in scopolia may worsen side-effects of TCAs-additive antimuscarinic effects) Yohimbine alone can cause hypertension, but lower doses cause hypertension when combined with TCAs Unknown mechanism (ginkgo t sedative effects of trazodone) St John s wort inhibits the uptake of serotonin and thereby t serotonin levels Avoid concomitant use. An SSRI may be a better alternative to be used with broom... 

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