Cardiac progenitor cell

In studies involving atrial and ventricular biopsies in sheep and humans, Messina et al. [84] isolated a cardiac progenitor cell that was c-Kit and capable of self-proliferating into a large number of cells. The authors also showed that human CSCs could participate in infarct repair in the murine model. 

Oh FI, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, Pocius J, Michael LFl, Behringer RR, Garry DJ, Entman ML, Schneider MD. Cardiac progenitor cells from adult myocardium homing, differentiation, and fusion after infarction. Proc Natl AcadSci U S A 2003 100 12313-12318. 

Gude, N. et al., Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population, Circ. Res., 99, 381, 2006. 

The first approach is to stimulate the endogenous repair mechanisms. Cardiac progenitor cells have recently been discovered, and their ability to trigger endogenous repair and potential for cardiac tissue regeneration has been recognized. However, the exact mechanism by which they promote cardiac regeneration remains unknown. 

Figure 19.1 Cardiac tissue engineering triad. Schematic representation of the interplay between the components of the cardiac tissue engineering triad. Biomaterials are key components for cardiac tissue engineering applications and play a critical role in this technology. MSC, mesenchymal stem cell ADSC, adipose stem cell iPS, induced pluripotent cell CPC, cardiac progenitor cell VEGF, vascular endothelial growth factor FGF, fibroblast growth factor NRG, neuregulin EPO, erythropoietin HGF, hepatocyte growth factor SDF-1, stromal cell—derived factor 1.

Padin-lruegas, M. E., Misao, Y., Davis, M. E., Segers, V. F., Esposito, G., Tokunou, T., Urbanek, K. et al. 2009. Cardiac progenitor cells and biotinylated insulin-Uke growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation, 120,876-887. 

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