Cardiac glycosides pharmacology

Rietbrock N, Woodcock BG. Handbook of Renal-Independent Cardiac Glycosides Pharmacology and Clinical Pharmacology. Chichester Ellis Horwood, 1989. 

Aronson JK. Book review Handbook of renal-independent cardiac glycosides pharmacology and clinical pharmacology, by N Rietbrock and BG Woodcock. Lancet 1989 2 1130-1. 

The pharmacological receptor of cardiac glycosides is the sarcolemmal Na+/K+-ATPase expressed on most eucaryotic membranes. It was characterised biochemically in 1957 by J. Skou, who was awarded with the Nobel Prize in chemistry in 1997. The sodium... 

Wang, L., Wible, B.A., Wan, X. and Ficker, E. (2007) Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking. The Journal of Pharmacology and Experimental Therapeutics, 320, 525—534. 

Hoffman BF, Bigger JT Digitalis and allied cardiac glycosides in Gilman AG, Goodman LS, Rail TW, Murad F (eds) The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan, 1985, pp 716-747. 

The heart muscle cells can also be reached directly. Thus, cardiac glycosides bind to the Luellmann, Color Atlas of Pharmacology All rights reserved. Usage subject to terms... 

Many aspects of the pharmacology, clinical pharmacology, and adverse effects and interactions of cardiac glycosides have been reviewed (1-12). 

Erdman E, Greeff K, Shou JC, editor. Cardiac Glycosides 1785-1984. Biochemistry, Pharmacology, Clinical Relevance. Darmstadt Steinkopff Verlag, 1985. 

Toxins in general are potent poisons. Nevertheless, the selectivity of action of some of these toxins means they have been harnessed in medical therapeutics (and even more widely in experimental pharmacology and physiology). Toxins that have been, or still are. us in medicine include atropine, botulinum toxin, cardiac glycosides, coichidne, eserine, hyoscine, picrotoxin, morphine, ouabain, strychnine, veratridine, vinca alkaloids and many more. All these work by an action at a defined molecular site, whether ion channel, neurotransmitter receptor, enzyme, pump or intracellular organelle. Those toxins that work at nonneuronal, or not specifically at neuronal sites (e.g. cholera toxin, pertussis toxin, cardiac glycosides, phospholipases) are discussed under TOXINS. 

Other factors may exhibit synergism in reactions with contrast media. In mice, contrast media with cardiac glycoside cause higher mortality than contrast media alone (593). Incompatibility of contrast media with other pharmacological agents has also been noted... 

Up to now the use of tissue culture from higher plants for production on an industrial scale has been successftd in only a few cases. On the other hand, small-scale, biotransformations of natural pure substances to new pharmacologically active compounds, e.g. cardiac glycosides, have been performed. 

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