Russian carcinogenicity

A Russian expert system, PASS (prediction of activity spectra for substances) [84], uses substructural descriptors called multilevel neighborhoods of atoms [85] to predict over 900 different pharmacological activities from molecular structure. These activities include a number of toxicity end points such as carcinogenicity, mutagenicity, teratogenicity, and embryotoxicity. The accuracy of prediction has been shown [86] to range from about 85% to over 90%. One-off predictions can be obtained free of charge on the PASS website [84]. 

Genin VA, Medvedovskiy AG, Voronin VM. 1975. [Increased carcinogenic activity during joint effect of hydrobenzene (sic) and benzidine sulfate.] Gig Tr Prof Zabol 6 28-31. (Russian)... 

Pliss GB. 1974. [Carcinogenic properties of hvdrazo-benzene.j Vopr Onkol 20 53-57. (Russian)... 

Pliss GB. 1963. [On some regular relationship between carcinogenicity of aminodiphenyl derivatives and the structure of substance.] Acta Unio Int Cancrum 19 499-501. (Russian)... 

Fediukovich, L. V. Egorova, A. B. (1991) Genotoxic effect of acrylates. Gig. Sanit., 62-64 (in Russian) lARC (1986) lARC Monographs on the Evaluation of the Carcinogenic Risks of Chemicals to... 

Khudoley, V.V., Gvildis, V.Y. Pliss, GB. (1989) Identification of some trihalomethanes in drinking water and assessment of their toxicity, mutagenicity, and carcinogenicity. Vopr. Onkol., 35, 837-842 (in Russian)... 

Khudoley W, Mizgirev IV, Pliss GB. 1986. Evaluation of the mutagenic activity of carcinogens and other chemical agents with Salmonella typhimurium assays. Vopr Onkol 32 73-80. (Russian)... 

Pylev LN. 1987. [The role of modifying factors in the carcinogenic effects of asbestos and asbestos-containing dusts.] Eksp Onkol 9 14-17. (Russian)... 

Pylev LN, Kogan FM, Kulagina TF. 1988. [Carcinogenic activity of asbestos cement dust.] Gig Tr Prof Zabol (July) 55-57 (Russian)... 

Moiseev GE, Benemanskii V. 1975. [Concerning the carcinogenic activity of low concentrations of nitrosodimethylamine during inhalation.] Vopr Onkol (Leningr) 21 107-109. (Russian)... 

Comfrey is a perennial herb used for the prevention of kidney stones nourishing and repairing bone and muscle and for the treatment of injuries such as burns and bruises. In Australia, comfrey is classified as a poison and its sales have been restricted in several regions. Many different commercial forms of comfrey are marketed, including oral and external products. Commercial comfrey is usually derived from the leaves or roots of Symphytum officinale (common comfrey). However, some products are also derived from Russian comfrey. Russian comfrey contains a very toxic pyrrolizidine alkaloid, echimidine, which is not found in common comfrey. However, common comfrey contains other hepatotoxic alkaloids, namely 7-acetylintermedine, 7-acetyllycopsamine and symphytine. The metabolites of these alkaloids are very toxic to the liver. Ridker et al. documented hepatic venocclusive disease associated with consumption of comfrey root. Long-term smdies in animals have also confirmed the carcinogenicity of comfrey in animal models. ... 

The fluorescence, ultraviolet and visible spectra of the series were reported in Russian [78] spectral shifts are related directly to LCAO MO calculations. Following the correlations between carcinogenicity and theoretical molecular electronic transition energies made by Mason [79—81], Birks [82], and Steele, Cusachs and McGlynn [83, 84] and in part experimentally confirmed by Sung and Lazar [85], the Russian results emphasise the importance of electronic transitions in the carcinogenic involvement of the series.]... 

Orlov VV, Vassiliev PM, Derbisher VE (1999) Computer system for estimation of carcinogenic risk of chemical production. In Proceeding of the 4th Russian scientific and practical conference with international participation Novelties in Envionmentalism and Safety of Living , Saint Petersburg, 16-18 June 1999, p 212... 

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