Carcinogenesis vitamin intake

Fenech, M., Baghurst, P., Luderer, W., Turner, J., Record, S., Ceppi, M., and Bonassi, S. (2005). Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability—Results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 26, 991-999. 

There have been several epidemiological and several case reports inversely relating ascorbic acid intake from food to human cancer mortality. These studies are interesting, but may be confounded with the fact that the same ascorbic acid containing foods, namely fruits and vegetables, also contain large amounts of vitamin A and fiber. Both vitamin A and fiber have been inversely related to human cancer mortality and have been shown to inhibit several types of chemically-induced carcinogenesis in animals. Therefore, the possible anti cancer effect of ascorbic acid may be due to other factors. 

Retinoids in Cancer Prevention and Treatment Since the discovery of vitamin A, the observation that the main effects of deficiency are hyperplasia and loss of differentiation of squamous epithelium has raised speculation that the vitamin may he associated with carcinogenesis. Either deficiency may be a risk factor for cancer or increased intake may be protective. Deficient animals develop more spontaneous tumors and are more sensitive to chemical carcinogens, whereas liver reserves of vitamin A are lower in patients with cancer than in controls. One of the genes repressed by retinoic acid is the myc-oncogene. 

The dose relationsl ps betweoi food constituents and dieir efficacies for prevention of "life style>rdated diseases" induding cemco have been proven in The dose relaticmsh s between food constituents and dieir efficacies ftn prevention of "life style dated diseases" induding cracer have been proven in recent decades. While attention has been frequently paid to anti-oxidative vitamins or pdyphcnols for the preventicm of carcinogenesis in rodents, the above-mentioned ubiquitous phytochemicals do not exclusively rqtresent the benefidal, cancer-protective effect of vegetable intake vdien the great diversity ai plant secondary metabolites is taken into account. 

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