Carcinogenesis Viral

MLL4 (KMT2D) Involvement in viral (hepatitis B) liver carcinogenesis [92] H3K4... 

The specific interaction of chemicals or radiation with DNA activate cdlular DNA repair processes which appear to play an important role in carcinogenesis. Eukaryotic cells show enhanced repair capacity for repair of viral nucleic add if the host cells are first damaged by chemicals or irradiation. The ihanced susceptibility to cancer of patients with defective repair systems, such as those with xeroderma pigmentosum, suggests that intact repair mechanisms are protective... 

Once inside the coil, virulent viruses turn off cellular macromolccular synthesis and disaggregate cellular polyribosomes, thus favoring a shift to viral synthesis. These viruses cause the ultimate destruction of the infected cell. In contrast, moderate viruses may stimulate host DNA, ntRNA, and protein synthesis—a phenomenon which may be of considerable importance in viral carcinogenesis. 

Cancer therapy and chemical, physical, and viral carcinogenesis from Carci nogenesi s Abstracts and Cancer Therapy Abstracts... 

Viral carcinogenesis Cyclosporin Sunil-Chandra Abatacept (CTLA-4-Fc Anon. Test system Usually requires... 

Flaitz CM, Hicks MJ. Molecular piracy the link to viral carcinogenesis. Oral Oncol 1998 34 448-53. 

Stephen J. O Brien (8), Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21701... 

Cell growth and differentiation Development Viral infection Carcinogenesis... 

Benzo[a]pyrene has also been shown to affect immune responses to viral infection. Benzo[a]pyrene can reversibly inhibit the induction of viral interferon in 32 different mammalian cell lines but only in the presence of S9 metabolic activation (Hahon and Booth 1988). This inhibition must occur at an early level and not affect viral interferon interactions because the activity of exogenous interferon was unaffected. In addition, influenza virus multiplication was also inhibited by activated benzo[a]pyrene. Benzo[e]pyrene had no effect on interferon induction. The authors suggest that benzo[a]pyrene s inhibition of interferon induction may be an early step in compromising the host s immune function, thereby allowing the induction of carcinogenesis. 

Ikeda K, Saitoh S, Suzuki Y. Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis A prospective observation of 2215 patients. J Hepatol 1998 28 930-938. 

The study of viruses has brought to light powerful tools for the study of human diseases. Tumor virology has survived its failure to find abundant viral agents of human cancer. The issue now is not whether viruses cause human tumors, as they may, but rather how much can be learned from tumor virology about mechanisms of carcinogenesis. 

Chiappini F, Gross-Goupil M, Saffroy R, et al. Microsatellite instability mutator phenotype in hepatocellular carcinoma in nonalcoholic and non-virally infected normal livers. Carcinogenesis. 2004 25 541-547. 

Okabe, H., Satoh, S., Kato, T., Kitahara, O., Yanagawa, R., Yamaoka, Y., Tsunoda, T., Furukawa, Y., and Nakamura, Y., 2001, Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray identification of genes involved in viral carcinogenesis and tumour progression. Cancer Res., 61 2129 - 2137. 

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