Structure-activity correlations carcinogenesis

Colburn and Boutwell [206] concluded that at least there does seem to be a positive correlation of tumorigenesis with one or both of the nucleic acids DNA and RNA. Very recently, it was stated that the critical experiments have yet to be done to ascertain which (if any) of the macromolecules to which hydrocarbons (or their expoxides) bind is the primary target that triggers the carcinogenic process [139]. From quantitative structure-activity analysis, Franke [207] suggests that microsomal arylhydrocarbon benzopyrene hydroxylase may be the first step in chemical carcinogenesis of polycyclic hydrocarbons. 

According to the two-region theory [44] of carcinogenesis of polycyclic aromatic hydrocarbons, following four parameters are used for the correlation between the molecular structure of polycyclic aromatic hydrocarbons and their careinogenic activities ... 

Residual QSARs forthe structural alert models derived in OECD-QSAR-step (i) are computed, considering the predicted activities in Table 3.40 the results are presented in Table 3.42. Considerable correlation was found, indicating the indirect influence of structural alerts on mutagenicity and carcinogenesis. 

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