Carboxyphenoxy valerate

The polymer composition and the sequence of the comonomers can be determined by HNMR as demonstrated in the analysis of the aromatic-aliphatic homopolymers [52], The aliphatic-aromatic diacids can be connected in a polymer in three ways, aliphatic moiety to aliphatic moiety, aliphatic to aromatic, and aromatic to aromatic moieties. The HNMR spectra of the carboxyphenoxy valerate (CPV) diacetate prepolymer and polymer are shown in Fig. 7. The methylenic protons of the aliphatic residue conjugated to the anhydride bond in the polymer appeared as two triplets (e) at 2.54 ppm and 2.72 ppm chemical shifts. The aromatic protons ortho to the anhydride bond appeared in two chemical shifts (a), a doublet at 7.90 ppm and at 8.10 ppm. The peaks at 2.72 and 8.10 were not observed in the spectrum of the prepolymer (Fig. 7). These peaks were explained by a chemical shift effect across the anhydride bond, affecting the absorbancies of the a-protons to the anhydride bond. These peaks were attributed to the three types of anhydrides present in the polymen the 2.54 ppm signal corresponds to the aliphatic-aliphatic anhydride bond, 2.72 ppm to aliphatic-aromatic, and 8.10 ppm to aromatic-aromatic anhydride bonds. Examination of the integration of these peaks revealed a ratio of 1 2 1, aliphatic-aliphatic, aliphatic-aromatic, and aromatic-aromatic moieties. This ratio implies an equal statistical distribution of alternating aromatic-aromatic and aliphatic-aliphatic units throughout the polymer backbone [52]. 

Monomer(s) structure acids S-(p-carboxyphenoxy) valeric, 8-(p-carboxyphenoxy) ootanoic, 1,3-bis(p-carboxyphenoxy) propane, 1,6-bis(p-oarboxyphenoxy) hexane, 1,6-bis(o-carboxyphenoxy) hexane, adipic, azeiaic, dodecanedicarboxylic, dodecanedioic, fumaric, isophthaiic, p-carboxyphenoxy acetic, pimelic, sebacic, suberic, terephthalic other erucic acid dimer, ricinoleic acid maleate, ricinoleic acid succinate, 12-hydroxystearic acid succinate photopolymerizable monomers, e.g., methacrylated sebacic acid Goepferich, A Tessmar, J, Adv. Dmg Delivery Rev., 54,911-32, 2002 Jain, J P Chirkara, D Kumar, N, Expert Opin. Drug Deliv., 5, 8,889-907,2008. 

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