Carbonyl difluoride detection

However, hexafluoroacetone is broken down almost completely87 over potassium tetrafluoro-cobaltate(III) at 250°C only traces of trifluoroacetyl fluoride are detected, the rest being carbon tetrafluoride and carbonyl difluoride. This shows that even if perfluoro ketones are formed in fluorination processes, they will break down, thus demonstrating that transition metal fluoride fluorination will not produce polyfluoro ketones. 

Before handling carbonyl difluoride, personnel should be equipped with suitable leak detection equipment and HF Antidote Gel (see Section 13.1.5). A solution of concentrated aqueous ammonia enables the detection of leaks by forming copious white fumes on contact of the respective vapours. Larger leaks are apparent from the formation of white fumes resulting from the hydrolysis of the COFj in moist air, and from the detection of the irritating and pungent odour. Any areas of equipment exposed to a COFj leakage should be cleaned up to remove any acid formed. 

Unlike phosgene, a system for the direct detection of carbonyl difluoride is not commercially available. However, it has been found in our own laboratories that DrSger tubes (see Section 3.2.3.1.2) used for phosgene monitoring also indicate the presence of COFj. These tubes could thus be calibrated for rough quantitative estimation by using standardized concentrations of COF [ICIlll]. 

As with phosgene (see Section 3.2.5.1), gas chromatography is a particularly useful technique for the determination of a broad range of concentrations of carbonyl difluoride. The thermal conductivity detector is the only detection system reported to be used for this compound. The detector response for the thermal conductivity detector is shown to be linear over a wide range of COF concentrations [559]. 

When air is heated to between 2000-6000 K and passed over a PTFE surface, carbonyl difluoride is detected by its emission infrared spectrum in the PTFE/air boundary layer [2239]. COF j has also been detected in an ablating flat plate air-PTFE laminar boundary layer [820,821] generated with a subsonic free stream of air (1 atm, 3000-6000 K) produced by an arc jet CO, COj, and NO were also observed in this experiment. 

Recently, novel polymethine carbonyl-dyes based on coumarin moiety and their boron difluoride complexes 9a-d and lOa-d [34—36] were evaluated as fluorescent dyes for the detection of native proteins using bovine serum albumin (BSA) as a model protein, and as probes for the nonspecific detection of proteins using a BSA/ sodium dodecyl sulfate (SDS) mixture [37]. Optical properties of these compounds in the absence and presence of BSA, as well as in SDS and BSA/SDS mixture, were measured in Tris-HCl buffer (pH 8.0) (Table 1). 

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