Carbon monoxide oxidase molybdenum

Carbon monoxide oxidase molybdenum, 662 Carbonylation asymmetric catalysts, 292 catalysts... 

Carbon monoxide serves as the sole carbon and energy source for the carboxydo bacteria under aerobic conditions. Using water as the oxygen donor, carbon monoxide oxidase catalyzes the hydroxylation of carbon monoxide, giving carbon dioxide or bicarbonate for assimilation. Most work has been carried out on the enzyme from Pseudomonas carboxydovorans.,ftJ7>W38 The activity of carbon monoxide oxidase is considerably stimulated upon anaerobic treatment with sulfide and dithionite, or by aerobic treatment with selenite. The binding of selenite to the oxidase specifically activates the CO — methylene blue reaction.1039 The molybdenum cofactor liberated from selenium-activated carbon monoxide oxidase does not contain selenium. Here, then, the... 

The results described in the previous sections have demonstrated the versatility of molybdenum as a reaction centre in biology. The molybdenum cofactor stands at the centre of an important network of cellular functions that are all catalyzed by molybdoenzymes. The similarities and differences in these reactions are of great interest, and relate clearly to the detailed arrangement of terminal sulfur and oxygen atoms. However, the unexpected results found for carbon monoxide oxidase and the requirement for selenium in some cases indicate that other factors are also important. 

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