Carbon monoxide anoxia

Carbon monoxide Anoxia, central vascular system, central nervous system, reproductive 25 50 50... 

ASPHYXIA The result of a diminished supply of oxygen to the blood and tissues and interference with the respiratory function. Simple anoxia may be caused by inert gases , e.g. nitrogen, and some flammable gases, e.g. methane. Toxic anoxia may be caused by certain substances, e.g. carbon monoxide and hydrogen cyanide, which interfere with the body s ability to transfer or utilize oxygen in the tissues. Rapid unconsciousness and death can occur in either case. 

Toxic anoxia caused by damage to Carbon monoxide cyanogen, hydrogen ... 

Levels below 19.5% oxygen can have detrimental effects if the body is already under stress, e.g. at high altitudes. Exposures below 18% should not be permitted under any circumstance. Other chemicals, e.g. carbon monoxide, result in toxic anoxia due to damage of the body s oxygen transport or utilization mechanism. 

Some substances, such as carbon monoxide and barbiturates, can deprive brain cells of oxygen or glucose - they produce anoxia - with potentially serious consequences for gray matter. Other substances, such as lead, hexachlorophene, and the antitubercular drug isoniazid, are capable of causing loss of myelin, a coating or sheath for the axon and dendrites that extend from the central unit (cell body) of neurons. Demyelination can occur in either the CNS or PNS. 

Carbon monoxide Interferes with oxygen transport by blood, resulting in the reduction of oxygen supply to the heart (chronic anoxia), heart and brain damage, impaired perception... 

Metabolism. The metabolic requirements of neurons depend heavily on the oxidation of glucose. Anoxia or ischemia quickly and severely inhibit neuronal function, so toxicants (e.g., cyanide, carbon monoxide) that cause anoxia or ischemia are indirect sources of neurologic damage. 

Carbon monoxide—produces anoxia and affects the cardiovascular and central nervous systems. The TLV-TWA is 25 ppm (ACGIH 1998). 

Toxicology of Flame Attack in Enclosed Spaces and "Toxicology of Carbon Monoxide and Anoxia, in Symposium on the Toxicological Aspects of the Flame Thrower, Dumbarton Oaks, 29 Jan 45. ETF 235-45. 

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