Carbohydrates Amphotericin

Carbohydrates, by fermentation or extraction Aclarubicin Acetyl digitoxin Amphomycin calcium Amphotericin B Asparaginase Bacitracin... 

Chizhov and colleagues have published (in the Russian literature) [151,152] a synthesis of the Ci-C, the C7-C12, and the C33-C37 segments of amphotericin B starting from carbohydrates. 

Polyene antibiotics which possess a free amino group, e.g. amphotericin B, react with carbohydrates or their derivatives under appropriate conditions, yielding A -glycosyl derivatives. These derivatives formed water-soluble salts. The N-glucosyl and -glucuronyl derivatives showed similar antifungal activity to the parent compound but reduced systemic toxicity [398,399] and proved effective when administered intraperitoneally in the treatment of experimental candidiasis in mice [400]. 

A number of syntheses of acyclic chain extended compounds have been reported this year. 2-Deoxy-D-glucose has been elaborated to 213 a precursor to the C14-C24 section of tautomycin, and a synthesis of the C1-C12 fragment 216 of amphotericin B utilizes a Wittig coupling of two carbohydrate components, the 3-deoxy-D-ribofuranose derivative 215 and the galactose-derived 214.91... 

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