Acetyl-digitoxin

Lelarge P, Bauer P, Royer-Morrot MJ, Meregnani JL, Larcan A, Lambert H. Intoxication digitalique apres administration conjointe d acetyl digitoxine et d amiodar-one. Ann Med Nancy Est 1993 32 307. 

Forzy P, Joram F. Thrombopenie severe en rapport avec une intoxication a I acetyl digitoxine. Sem Hop Paris 1989 65 235-6. 

Carbohydrates, by fermentation or extraction Aclarubicin Acetyl digitoxin Amphomycin calcium Amphotericin B Asparaginase Bacitracin... 

Intestinal absorption of digoxin is less complete compared to digitoxin. In order to improve absorption, acetylated- and methylated-digoxin derivates were developed. Digitoxin is metabolised in hepatic microsomal enzymes and can be cleared independently from renal function. The therapeutical serum level of digoxin is 0.5-2.0 ng/ml and 10-35 ng/ml of digitoxin. Steady state plateau of therapeutic plasma concentrations is reached after 4-5 half-life-times using standard daily doses [5]. 

This soluble, cytosolic enzyme catalyses the 15 -0-acetylation of cardenolide tri- and tetrasaccharides. Using acetyl co-enzyme A as the acetyl donor, acetyl co-enzyme A digitoxin 15 -0-acetyltransferase (DAT) activity was detected... 

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