Carbohydrate metabolism disorders

Use with caution in patients with carbohydrate metabolism disorders (e.g., diabetes mellitus) and patients with impaired cardiac function. 

Carbohydrate metabolism disorders like hereditary fructose intolerance and galactosemia result in acute, leading to chronic, liver damage through depletion of available ATP (by depleting the total phosphate pool) as well as aberrant glycosylation [1, 2]. Gluconeogenic defects like pyruvate carboxylase or 1,6-fructose-bis-phosphatase deficiency... 

Foods for persons suffering from carbohydrate metabolism disorders... 

Greville GD Vol 1, p 297, in Carbohydrate Metabolism and Its Disorders. Dickens F, Randle PJ, Whelan WJ (editors). Academic Press, 1968. 

For disorders of carbohydrate metabolism and the primary lactic acidoses, see Chapter 34. 

One class of carbohydrate and fatty acid metabolism disorders is caused by defects in enzymes that function in the brain 703... 

Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia and abnormalities in carbohydrate, fat, and protein metabolism. It results from defects in insulin secretion, insulin sensitivity, or both. Chronic microvascular, macrovascular, and neuropathic complications may ensue. 

Thiamine (vitamin Bi), in the form of thiamine diphosphate (TPP), is a coenzyme of some considerable importance in carbohydrate metabolism. Dietary deficiency leads to the condition beriberi, characterized by neurological disorders, loss of appetite, fatigue, and muscular weakness. We shall study a number of... 

Structural relationships suggest that the extended carbohydrate scaffolds obtainable by such tandem aldolizations may be regarded as metabolically stable mimetics of oligosaccharides, in particular of C-glycosides that are hydrolytically stable. The latter class of compounds shares an interest for potential therapeutic applications with the class of so-called aza sugars that have commanded attention in recent years as potent glycoprocessing inhibitors for the treatment of diabetes and other metabolic disorders, as well as for the blocking of viral or microbial infection and metastasis. 

Chen, Y.-T., Chapter 350 Glycogen storage diseases and other inherited disorders of carbohydrate metabolism. Harrison s Text online. 2002, accessed 4/2/02. E. Braunwald, A.S. Eauci, K. J. Isselbacher, D.L. Kasper, S.L. Hauser, D.L. Longo, and JL. Jameson, eds. 

In animals, manganese deficiency results in wide-ranging disorders, e.g,. impaired growth, abnormal skeletal structure, disturbances of reproduction, and defective lipid and carbohydrate metabolism. Although overt manganese deficiency has nol been induced in humans, some forms of epilepsy... 

Roehrig, K. L., Carbohydrate Biochemistry and Metabolism. Westport, Ct. Avi Publishing Co., 1984. Carbohydrate metabolism discussed at a rather elementary level. Covers several topics that are not included in this book, such as disorders of carbohydrate metabolism with brief discussions of many types of human genetic diseases in which carbohydrate metabolism is impaired. 

Myotoxicity linked to ezetimibe has been described in a 45-year-old overweight man with McArdle disease, which is the most common disorder of muscle carbohydrate metabolism, caused by mutations in the gene that encodes myophosphorylase (5). 

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