Carbohydrate-functionalized fluorescent polymer

Disney M, Zheng J, Swager TM, Seeberger P (2004) Detection of bacteria with carbohydrate-functionalized fluorescent polymers. J Am Chem Soc 126 13343-13346... 

Scheme 11.2-4 Synthesis of the carbohydrate-functionalized fluorescent polymer 17 for the detection of pathogenic bacteria.

M.D. Disney, J. Zheng, T.M. Swager, P.H. Seeberger, Detection of Bacteria with carbohydrate-functionalized fluorescent polymer,... 

The refractive index (RI) detector is the only detector in LC that responds to almost every compound. It is very useful for detecting species that are not ionic, do not absorb in the UV and do not fluoresce, e.g. polymers and carbohydrates. The detection principle involves measuring the difference in the refractive index of the background eluent and that of the eluent with analyte. The refractive index of an analyte is a function of its concentration so any change in concentration is reflected as a change in the RI. The... 

Liu and coworkers [103] reported that bromo-alkane functionalized polymers can be glycosylated in near quantitative yield (98%) simply by the reaction of the bromo groups with a thio-sugar. This thioether formation reaction was utilized to covalently attach protected or unprotected carbohydrate residues to fluorescent conjugated polymers. 

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