Carbohydrate dendrimer

R. Kikkeri, I. Garcia-Rubio, and P. H. Seeberger, Ru(II)-carbohydrate dendrimers as photoinduced electron transfer lectin biosensors, Chem. Commun. (2009) 235-237. 

K. Bezouska, Design, functional evaluation and biomedical applications of carbohydrate dendrimers (glycodendrimers ), Rev. Mol. Biotechnol., 90 (2002) 269-290. 

The molecular scaffolds of carbohydrate dendrimers can be varied in many different ways carbohydrates can act as core unit, serve for branching, or function as terminal groups [47]. Moreover, they are also suitable for supramolecular bonding and for the transport of active ingredients. 

The synthesis of a carbohydrate dendrimer consisting solely of mannopyrano-sides was accomplished via a convergent route [53]. 

Ashton PR, Balzani V, Clemente-Leon M, Colonna B, Credi A, Jayaraman N, Raymo FM, Stoddart JF, Venturi M (2002) Ferrocene-containing carbohydrate dendrimers. Chem Eur J 8 673-684... 

A potentially attractive generation of dendritic architectures, mostly bearing carbohydrate entities, has appeared and will provide a useful pool of hydrophilic ligands [73, 74]. In such a way ferrocene-containing carbohydrate dendrimers open future prospects [75]. 

Click type approaches for assembling full carbohydrate dendrimer... 

Assembling full carbohydrate dendrimer by amide coupling... 

Another interesting application of water-soluble dendrimers has been described by Stoddart and co-workers and utilises ferrocene containing carbohydrate dendrimers [102]. A ferrocene core substituted with glucopyranosyl residues was found to form complexes with 3-cyclodextrin and has formed the basis for a supramolecular switch. 

Wrodnigg TM, Eder B (2001) The Amadori and Heyns Rearrangements Landmarks in the History of Carbohydrate Chemistry or Unrecognized Synthetic Opportunities 2/5 115 -175 Wyttenbach T, Bowers MT (2003) Gas-Phase Confirmations The Ion Mobility/Ion Chromatography Method. 225 201 -226 Yamaguchi H, Harada A (2003) Antibody Dendrimers. 228 237-258... 

In this decade, all chemistry research fields have adopted and/or applied the dendrimers and/or dendrimer methodologies. The table of contents of this series. Topics in Current Chemistry Dendrimers Volumes I-IV, clearly indicates this situation [1-4], that is, the concept of dendritic compounds has already been introduced in host-guest and/or supramolecular chemistry (Vol. I/Chap. 2, Vol. Il/Chaps. 3,4, Vol. IV/Chap. 3), chiral chemistry (Vol. I/Chap. 4), electrochemistry (Vol. I/Chap. 6, Vol. Ill/Chap. 3), heteroatom and/or organometalHc chemistries (Vol. I/Chap. 3, Vol. Il/Chaps. 2,5, and Vol. IV/Chap. 4), and carbohydrate chemistry (Vol. IV/Chap. 6), as well as applied in the field of medicine (Vol. Il/Chap. 6) and nanoscience (Vol. Ill/Chap. 4). The dendrimer methodology is expected to be used in future novel science as a conventional chemistry concept. 

Scheme 4. Antibody dendrimers prepared by the combination of IgM with IgG attached hapten to the carbohydrate moiety in the Fc fragment... 

The same research group extended their studies, proposing a systematic investigation of the core activities for different carbohydrate densities during biosensing processes.279 Three new mannosylated dendrimers with a Ru(bipy)3 core unit were synthesized, and the influence of the number and size of dendritic branches on the rate of electron and energy transfer, as well as the lectin-biosensing abilities (Scheme 41),... 

In summary, results of in vivo experiments showed the effectiveness of carbosilane dendrimers having clustered Pk carbohydrate moieties, and the complete neutralization potency against STL-II was discovered when dumbbell-shaped dendrimers were identified as potent candidate inibitors. Although the precise mechanism of action remains to be elucidated, this type of inhibitor provided a new strategy for the detoxification of SLTs present in circulation. 

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