Antibody dendrimer

Wrodnigg TM, Eder B (2001) The Amadori and Heyns Rearrangements Landmarks in the History of Carbohydrate Chemistry or Unrecognized Synthetic Opportunities 2/5 115 -175 Wyttenbach T, Bowers MT (2003) Gas-Phase Confirmations The Ion Mobility/Ion Chromatography Method. 225 201 -226 Yamaguchi H, Harada A (2003) Antibody Dendrimers. 228 237-258... 

Fig. 3. Haptens and multivalent antigens prepared in this syudy. The viologen derivative, 4,4 -bipyridinium, l-(carboxypentyl)-l -methyl-dichloride (1), divalent antigen 2, and trivalent antigen 3. Anti-porphyrin antibodies were elicited for [5-(4-carboxyphenyl)-10,15,20-tris-(4-methylpyridyl)]porphine (3MPylC) or meso-tetrakis(4-carboxyphenyl)porphine (TCPP). meso-Tetrakis(4-methylpyridyl)porphine (TMPyP) was used to investigate the specificity of the antibody dendrimer for porphyrins...

Preparation of Antibody Dendrimers and their Topoiogicai Structures... 

Scheme 3. The synthetic route of the complete antibody dendrimers. An ideal structme of the dendritic supramolecule is shown as G1...

The similar antibody dendrimers are prepared by the other route as shown in Scheme 4. The building block used as a branch was prepared by the specific... 

Scheme 4. Antibody dendrimers prepared by the combination of IgM with IgG attached hapten to the carbohydrate moiety in the Fc fragment... 

Fig. 11a,b. Binding affinities of IgG, IgM, and the antibody dendrimer (Gl) with the cationic porphyrin (TMPyP) (a) and those with the anionic porphyrin (TCPP) (b) estimated by ELISA... 

Fig. 12a,b. The sensorgrams for the binding of the antibody dendrimer (a) or IgG (b) to the anionic porphyrin immobilized onto the surface of the sensor chip. Phosphate borate buffer (0.1 M, pH 9.0) was used. TCPP was immobilized via hexamethylenediamine spacer onto the sensor chip and then a solution of IgG or the dendrimer was injected to the flow cell. After 60 s from the injection of the antibody solutions, flow ceU was filled with buffer... 

Kobayashi, H., Sato, N., Saga, T., Nakamoto, Y., Ishimori, T., Toyama, S., Togashi, K., Konishi, J., and Brechbiel, M.W. (2000) Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity. Eur. J. Nucl. Med. 27, 1334-1339. 

Patri, A.K., Myc, A., Beals, J., Thomas, T.P., Bander, N.H., and Baker Jr., J.R. (2004) Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapy. Bioconjugate Chem. 15, 1174-1181. 

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