Carbenoxolone sodium

Steer, H. W., and Colin-Jones, D. G. (1975), Mucosal changes in gastric ulceration and their response to carbenoxolone sodium. Gut BMJ, 16,590-597. 

Caution. Carbenoxolone sodium powder is irritating to nasal membranes. Dissociation Constant. pKa 6.7,7.1. 

Ultraviolet Spectrum. Carbenoxolone sodium aqueous acid— 248 nm aqueous alkali—257 nm (A = 172 b). 

Infra-red Spectrum. Principal peaks at wavenumbers 1562,1642, 1715, 1289, 1261,1210 (carbenoxolone sodium, KBrdisk). 

Hexamethonium Tartrate 544.2 Suxamethonium Iodide 614.7 Carbenoxolone Sodium... 

Lewis J. Carbenoxolone sodium in the treatment of peptic ulcer. JAMA 1974 229 460-2. 

Geismar P, Mosbech J, Myren J. A double-blind study of die effect of carbenoxolone sodium indie treatment of gastric ulcer. ScandJ Gastroenterol (1973) 8,251-6. 

Turpie AGG, Thomson TJ. Carbenoxolone sodium in die treatment ofgastric ulcer withspecial reference to side-effects. Gut( 96S) 6, 591-4. 

Baron A, Sullivan S, eds. Carbenoxolone Sodium Maintenance carbenoxolone sodium in the prevention of gastric ulcer recurrence. London Butterworths 1970 p. 103-16. 

Horwich L, Galloway R. Treabnent of gastric ulceration with carbenoxolone sodium clinical and radiological evaluaticn. BM/(1965) 2,1274-7. 

M( itgomeiy RD Side effects of carbenoxolone sodium a stuffy of ambulant therajy of s-tric ulcer. Gut 96T) 8,148-50. 

Carbenoxolone disodium Carbenoxolone, disodium salt Carbenoxolone sodium. See Disodium succinoyl glycyrrhetinate... 

J.M, Robson and R.M, Sullivan, Eds, Symp, on Carbenoxolone Sodium, Butterworth,... 

Recent clinical trials have revealed that two terpenoid derivatives of quite different chemical constitutions may hold some promise as useful chemotherapeutic agents in the treatment of gastric ulcers, although accurate assessment of their therapeutic potentialities must await the fullness of time. These compounds are the disodium salt of the hemisuccinate ester (LXVIII) of 18 -glycyr-rhetinic acid (approved name Carbenoxolone sodium) [505 a] and the geranyl ester (LXIX) of farnesylacetic acid (approved name Gefarnate). 

Carbenoxolone sodium was prepared essentially from considerations [506] of the concept of drug latentiation [507, 508] in order to secure a water-solubi-... 

The anti-ulceric properties of Carbenoxolone sodium throw open not only the question of its precise mechanism of action, but also the question of the exact relationship of its activity to the activities of certain other triterpenoids [539]. These include/ -amyrin, which is stated [540] to exhibit anti-inflammatory properties similar to those of the glucocorticoids aescin, the complex glycoside of 16-acetyl-21-tiglyloxyprotoaescigenin (LXX) [541] which exhibits anti-oede-matous properties [542-546] without showing beneficial effects on connective... 

Initially it was found that Carbenoxolone sodium did not show the same efficacy against duodenal ulcers that it seemed to show against gastric ulcers but as a result of metabolic studies in the rat [564] indicating virtually complete absorption of glycyrrhetinic acid from the stomach and its metabolism by the liver so that only metabolic end-products being secreted into the bile could be coming into contact with the duodenum, presentation of Carbenoxolone sodium in positioned-release capsule form has been initiated as an approach to the treatment of duodenal ulcers. 

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