Tobramycin Carbenicillin

Henderson JL, Polk RE, KUne BJ. In vitro inactivation of gentamicin, tobramycin, and netilmicin by carbenicillin, azlocUlin, or mezlocillin. Am J Hosp Pharm 1981 38(8) 1167-70. 

Mpller NE, Eriksen KR, Feddersen C, et al. Chemotherapy against Pseudomonas aeruginosa in cystic fibrosis A study of carbenicillin, azlocillin, or piperacillin in combination with tobramycin. Eur J Respir Dis 1982 63 130-139. 

Aminoglycoside antibiotics (257), including kanamycin A, tobramycin, and gentamicin C complex, have been acylated with 1 mole of disodium carbenicillin (258) to give monoacylated derivatives (e.g., 259) (compounds 257-259). The resulting compounds were devoid of antibacterial activity against several strains tested, however, and showed no toxicity [135]. 

A fluoroquinolone a tetracycline gentamicin A fluoroquinolone amikacin a tetracycline trimethoprim-sulfamethoxazole cefotaxime, ceftizoxime, ceftriaxone, cefepime, or ceftazidime Gentamicin, tobramycin or amikacin trimethoprim-sulfamethoxazole ciprofloxacin, ticarcillin, mezlocillin, or piperacillin aztreonam cefotaxime ceftizoxime ceftriaxone cefepime or ceftazidime Ampicillin gentamicin, tobramycin, or amikacin carbenicillin, ticarcillin, mezlocillin, or piperacillin gentamicin, tobramycin, or amikacin amoxicillin/clavulanic acid ticarcillin/clavulanic acid piperacillin/tazobactam ampicillin/sulbactam trimethoprim-sulfamethoxazole imipenem or meropenem aztreonam a fluoroquinolone another cephalosporin... 

Noninterfering amikacin, apalcillin, carbenicillin, cefoperazone, clindamycin, eiythromy-cin, gentamicin, penicillin, piperacillin, ticarcillin, tobramycin, vancomycin... 

Noninterfering amikadn, carbenicillin, cefazolin, cefoperazine, cefoxitin, chloramphenicol, ciprofloxacin, gentamicin, imipenem, moxalactam, oxacillin, ticeircillin, tobramycin, vancomycin... 

Other reports similarly describe unusually low gentamicin levels in patients with impaired renal function, given carbenicillin, piperacillin," or ticarcillin. > >" The half-life of gentamicin has been reported to be reduced by carbenicillin or piperacillin by about one-half or one-third. >">" Similarly, unusually low tobramycin levels have been reported in patients with impaired renal function, who were given carbenicillin, piperacillin or ticarcillin."... 

Aerosol antibiotics in controlled studies improved lung function and reduced the number of acute hospital admissions in patients with cystic fibrosis. Minimal drug hypersensitivity has been reported, and there is no solid evidence that the small increase in resistance to some antibiotics, associated with the use of aerosol antibiotics, is in any way detrimental to the patients (for review, see 161). The drugs used are, for example, tobramycin, carbenicillin, and gentamicin. 

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