Carbamoylamino acid

It has been shown recently that papain exhibits hydantoinase activity. This enzyme of plant origin hydrolyzes not only 5-monosubstituted but also 5,5-disubstituted hydantoins to the corresponding N-carbamoylamino acids. Since chemical hydrolysis of the latter yields the corresponding amino acids, this approach may be of interest in amino acid synthesis [145],... 

Commeyras and co-workers proposed for the first time a prebiotically relevant synthetic pathway [143,144]. They established that the nitrosation of N-carbamoylamino acids 25 (otherwise believed as unreactive in prebiotic environments) by nitrogen oxides (typically obtained by mixing O2 and NO) quantitatively releases NCA. Although first tested in organic solvent [ 143], the reaction proved to work in the solid state [144], and also in aqueous solution [145], where the NCA can be observed for ca. 1 h prior to its conversion into either free amino acids or peptides. 

Figure 3 Plausible prebiotic pathways for the formation of a-amino acid N-carboxyanhydrides 21 from free amino acids, N-carbamoylamino acids 20, or activated a-amino acid derivatives 22.

AMINOCARBONYL)AMINO)PHENYL)ARSINIDENE)BI SfTHIO)BISACETIC ACID BIS(CARBOXYMETHYL-MERCAPTO)(p-UREIDOPHENYL)ARSINE BIS(CARBOXYMETHYLTHIO)(p-UREIDOPHENYL)-ARSINE (p-CARBAMOYLAMINO)PHENYLARSINO-BIS(2-THIO-ACETIC ACID) CC 914 C.C. No. 914 MERCAPTOACETIC ACID, DIESTER with DITHIO-p-UREIDOBENZENEARSONOUS ACID PHENYL UREA-p-DI(CARBOXYMETHYL) THIOARSENITE THIOCARBARSONE (p-... 

CARBAMONITRILE see COH500 (p-CARBAMOYLAMINO)PHENYLARSINOBIS(2-THIO-ACETIC ACID) see CBI250 N-CARBAMOYLARSANILIC ACID see CBJOOO 1-CARBAMOYLFORMIMIDIC ACID see OLOOOO CARBAMOYLHYDRAZINE see HGUOOO p-((CARBAMOYLMETHYL)AMINO)-BENZENEARSONIC ACID see CBJ750 N-(CARBAMOYLMETHYL)ARSANILIC ACID see CBJ750... 

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