Carbamoyl chloride, reaction with aromatic

Reactions with nucleophiles other than alcohols can produce other carbonic acid derivatives. For example, reaction with anhydrous ammonia yields urea, 0 = C(NH2)2. Aromatic primary amines can, depending on reaction conditions, react with phosgene to form carbamoyl chlorides (Csuros et al., 1969). 

The preparation of amides by the treatment of amines with acyl haUdes is a very general reaction. When phosgene is the acyl hahde, both aliphatic and aromatic primary amines or their salts give carbamoyl chlorides, which can be regarded as substituted chloroformamides, CICONHR. 

Most carbamates used as insecticides are esters of aromatic and heterocyclic hydroxy derivatives of N-methyl- and N,N-dimethylcarbamic acids. They are usually prepared by the reaction of methyl- or dimethylcarbamoyl chloride with the alkali metal salt of the corresponding hydroxy derivative, or alternatively, the hydroxy derivative is carbamoylated with methyl isocyanate (Gysin, 1952). 

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