Colestipol Carbamazepine

Drugs that may affect tetracyclines include antacids containing aluminum, calcium, or magnesium iron salts zinc salts barbiturates bismuth salts carbamazepine cholestyramine colestipol phenytoin rifamycins urinary alkalinizers (eg, sodium lactate, potassium citrate). 

Steroids, Systemic, Tables VI-1 and VI-2 Interactions T Effects Wf cyclosporine, estrogens, OCPs, macrolides T effects OF cyclosporine T effects W/ aminog-lutethimide, antacids, barbiturates, carbamazepine, cholestyramine, colestipol. 

Interferes w/ DNA synth Dose Adults. Anaerobic Infxns 500 mg IV q6-8h Amebic dysentery 750 mg/d PO for 5-10 d Trichomoniasis 250 mg PO tid for 7 d or 2 g PO X 1 C. difficile 500 mg PO or IV qSh for 7-10 d (PO preferred IV only if pt NPO) Vaginosis 1 applicator-full intravag bid or 500 mg PO bid for 7 d Acne rosacea/skin Apply bid Peds. 30 mg/ kg PO/IV/d q6H, 4 g/d max-s-. Amebic dysentery 35-50 mg/kg/24 h PO in 3 -s- doses for 5-10 d Rx 7-10 d for C. difficile-, in hepatic impair Caution [B, M] Avoid EtOH Contra 1st tri of PRO Disp Tabs, caps, IV, topical lotion, intravag gel, cream SE Disulfiram-like Rxn dizziness, HA, GI upset, anorexia, urine discoloration Interactions t Effects W/ cimetidine T effects OF carbamazepine, fluorouracil, Li, warfarin -1- effects W/ barbiturates, cholestyramine, colestipol, phenytoin EMS t Effects of anticoagulants concurrent EtOH use can cause disulfiram-like Rxn (tach, N/V, sweating, flushing, headache, blurred vision, confusion) may cause a metallic taste and discolored urine OD May cause N/V/D, numbness in hands and feet, Szs, and loss of coordination symptomatic and supportive... 

Phenytoin, carbamazepine, phenobarbital, rifampin, rifabutin Iopanoic acid, ipodate, amiodarone, beta-blockers, corticosteroids, propylthiouracil, cholestyramine, colestipol, aluminium hydroxide, sucralfate, ferrous sulfate, some calcium preparations Interferon-c/, interleukin-2... 

Cole tyramine 8 g did not affect the absorption of carbamazepine 400 mg in 6 healthy subjects, whereas colestipol 10 g reduced it by 10%. Both colestyramine and colestipol were given as a single dose 5 minutes after the carbamazepine. This small reduction is unlikely to be clinically important. 

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