Progesterone capsules

Progesterone capsules and gel Progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency (8% gel). 

Progesterone capsules contain micronized progesterone for oral administration. Capsules are available in multiple strengths to afford dosage flexibility for optimum management. Capsules contain 100 or 200 mg micronized progesterone. The inactive ingredients for 100 mg cap-... 

Cicinelli E, de Ziegler D, Alfonso R, et al. Endometrial effects, bleeding control, and compliance with a new postmenopausal hormone therapy regimen based on transdermal estradiol gel and every-other-day vaginal progesterone in capsules a 3-year pilot study. Fertil Steril. 2005 83 1859-1863. 

However, progesterone, in a finely micronized form, is marketed (Prometrium) in large-dose capsules (100 mg and 200 mg) forthe treatment of some menstrual conditions. Micronization increases the bioavailability of insoluble APIs (see Chemical Engineering). 

Kleinstein, J. (2005), Efficacy and tolerability of vaginal progesterone capsules (Utrogest 200) compared with progesterone gel (Crinone 8%) for luteal phase support during assisted reproduction, Fertil. Steril., 83,1641-1649. 

Kim, S., Kengaku, K., Tanaka, T., and Kamomae, H. (2004), The therapeutic effects of a progesterone-releasing intravaginal device (PRID) with attached estradiol capsule on ovarian quiescence and cystic ovarian disease in postpartum dairy cows,/. Reprod. Dev., 50,341-348. 

The intrauterine administration of progesterone, contained in a silastic capsule attached directly to a Lippes loop (see Figure 5.6) and introduced into the uterus in the usual way, Im recently been reported by Scommegna,... 

Preparation of capsules, creams, suppositories or eye drops with steroids such as progesterone, testosterone, estradiol, and estriol. 

The initial, but not the subsequent decline in release rate can be largely eliminated by increasing the wall thickness of the tubes. This is illustrated in Fig. 17 and 18 for both testosterone and progesterone release from poly(caprolactone) capsules. 

Fig. 17 - Effect of wall thickness on the release rate of progesterone from poly(caprolactone) capsules...

Figure 1. PLA capsules containing 30% by weight Progesterone after contacting with plasma for 140 days.

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