Capillary electromigration techniques mass spectrometry

On-line conpling of capillary electromigration techniques with nuclear magnetic resonance spectroscopy [5] and matrix-assisted laser desorption/ionization (MALDl) time-of-flight (TOF) mass spectrometry [6] has also been reported. [Pg.157]

The hyphenation of capillary electromigration techniques to spectroscopic techniques which, besides the identification, allow the elucidation of the chemical structure of the separated analytes, such as mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) has been widely pursued in recent years. Such approaches, combining the separation efficiency of capillary electromigration techniques and the information-rich detection capability of either MS or NMR, are emerging as essential diagnostic tools for the analysis of both low molecular weight and macromolecular compounds. [Pg.170]

Mass spectrometry provides detailed information regarding molecular weights and structures from extremely small quantities of materials. Several types of ionization sources can be employed for the on-line hyphenation of capillary electromigration techniques with MS, which include... [Pg.170]

Capillary-electromigration separation techniques are coupled to mass spectrometry (CE-MS) by interfaces based on proven LC-MS designs [41,49,80-85]. In early... [Pg.744]