Cap gene

Chemical signals Jdrom host cuticle/ jiext2hr /next 4-6 hr, expression) of cap genes ... 

College of American Pathologists (CAP), Gene Patents Detrimental to Care, Training, Research (July 5,2000), www.cap.org/html/advocacy/issues/genetalk.html (last visited June 21, 2002). 

Clark, K. R., Voulgaropoulou, F. and Johnson, P. R. (1996). A stable cell line carrying adenovims-inducible rep and cap genes allows for infectivity titration of adeno-associated vims vectors. Gene Ther. 3, 1124—1132. 

Conway, J. E. et al. (1999). High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex vims type I vector expressing AAV-2 Rep and Cap. Gene Ther. 6, 986-993. 

Adeno-associated virus contains linear single-stranded DNA genome comprising only rep and cap genes non-immunogenic replication requies co-infection with lack of suitable packaging cell lines lowtiters (105—106) virus particles/ml) small DNA insertion capacity ( 4.7kb) adenovirus or other viruses... 

Fig. 2.1 The single-stranded DNA genome of AAV. The inverted terminal repeats (ITRs) flank the two open reading frames rep and cap. The rep gene encodes four nonstructural proteins -Rep78, Rep68, Rep52, and Rep40. The cap gene encodes three structural proteins - VPl, VP2, and VP3. The location of the promoters, p5, pl9, and p40 are depicted by arrows...

Fig. Z3 Viral vector production. The rAAV Vector plasmid contains the therapeutic gene flanked by the ITRs, usually of AAV2. The helper plasmid contains the rep and cap genes, as well as the adenoviral genes needed for replication. Both plasmids are transiently transfected into HEK293 cells that express the adenovirus ElA and ElB gene products...

Drosophila Cap Genes Are Transcribed in Broad Bands of Cells and Regulate One Another... 

The adeno-associated virus (AAV) is a nonpathogenic, ssDNA virus belonging to the Parvoviridae family of viruses. This virus has two genes The cap gene encodes for three viral coat proteins, and the rep gene encodes for four proteins involved in viral replication and integration. This virus needs additional genes to replicate that are provided by the helper virus, which usually is the adenovirus or herpes virus. Interest in this virus as a vector arose from the... 

Vincent KA, Piraino ST, Wadsworth SC. Analysis of recombinant adeno-assoeiated virus packaging and requirements for rep and cap gene products. J Virol 1997 71 1897-1905. 

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