Cannabis sesquiterpene

A sesquiterpene has been isolated from the essential oil of Cannabis Indica. This may fairly be considered a definite body, as it has been isolated by many different observers and described by them at different times. Valenta first mentions it. Vignolo describes it as a mobile liquid boiling at 256°, of specific gravity -897 at 15°, and slightly laevo-rotatory. Wood, Spivey, and Easterfield give the boiling-point as 258° to 259°, the specific gravity as -898 at 18°, and the rotation as - 8-6°. 

Lemberkovics, E., P. Veszki, G. Verzar-Petri and A. Trka. Study on sesquiterpenes of the essential oil in the inflorescence and leaves of Cannabis sativa L. var. Mexico Sci Pharm 1981 49 401-408. 

Sesquiterpene ana Cannabis satiTa B II351. Seaqniterpen ana afrikaniichem SandelhoIzU B II352. 

Indian Hemp Oil is obtained by subjecting the flowering twigs of Cannabis Indica to steam distillation. According to Yalenta the resulting oil is of thin consistency, and possesses an agreeable aromatic odour. It boils between 248 and 268 . Its specific gravity is about 930, and optical rotation - 10 , and it appears to consist chiefly of a sesquiterpene, which has been named cannibene. 

CHAllENCtl Synthesis of the sesquiterpene bergamotene, a trace component of cannabis oil, proceeds from the alcohol shown here. Suggest a sequence to complete the synthesis. 

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