Cannabis hallucinogenic properties

These hallucinogenic properties were recognized when Cannabis was administered in a variety of ways. The Scythians threw hemp seeds on hot rocks... 

A >tetrahydrocannabinol is one of the active principles of cannabis (constituent of marijuana or hashish from Cannabis sativa) with lower psychoactivity than A -tetrahydrocannabinol. It is a cannabinoid receptor agonist and has (euphoric) sedative and mild PSYCHOTROPIC (hallucinogenic) properties, and ANTIEMETIC activity. A >tetrahydrocannabinol (A -tetrahydrocannabinol) is an active cannabinoid. It is a constituent of marijuana. The active (6aR,10aR)-(-)-trans-form = dronabinol. It is a CANNABINOID RECEPTOR AGONIST and has (euphoric) SEDATIVE and mild PSYCHOTROPIC (hallucinogenic) properties, and ANTIEMETIC activity. 

The resin secreted by Cannabis indica and Cannabis sativa, varieties of hemp, is known variously as marijuana, hashish or bhang and is abused as a hallucinogenic drug. It appears however to have some beneficial properties and is currently under test as an antiemetic in cancer therapy. The secretion contains a number of interrelated oxygen heterocycles, some of which are shown in Scheme 281, which attempts to indicate their biosynthetic relationships (70MI22401). The cannabinoids are probably derived from a monoterpene unit based on p-menthane and 5-n-pentylresorcinol (olivetol), acting the part of a polyketide. 2,2-Dimethylchromene biosynthesis also requires the intervention of an isoprene fragment. 

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