Cannabinoids gastrointestinal

Molecular target Gastrointestinal lipases Serotonin and noradrenaline transporter Cannabinoid-1 receptor... [Pg.159]

Shook JE, Burks TF. (1989). Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. J Pharmacol Exp Ther. 249(2) 444—49. [Pg.565]

CNS, central nervous system GI, gastrointestinal SERT, serotonin reuptake transporter NET norepinephrine reuptake transporter CB, cannabinoid tid, three times daily qd, daily. [Pg.831]

One particular feature of plant-derived cannabinoids is their high lipid solubility, which indicates that limited gastrointestinal absorption and bioavailability are significant barriers to their development as therapeutics. For this reason cannabis is traditionally smoked, providing the most predictable and titratable route for administration. For therapeutic development pulmonary deliveries of cannabinoid aerosols are under investigation as an alternative. [Pg.498]

Izzo AA, Fezza F, Capasso R, Bisogno T, Pinto L, luvone T, Esposito G, Mascolo N, Di Marzo V, Capasso F (2001) Cannabinoid CBl-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation. Br J Pharmacol 134 563-570... [Pg.179]

Pertwee RG (2001) Cannabinoids and the gastrointestinal tract. Gut 48 859-867 Pertwee RG, Fernando SR (1996) Evidence for the presence of cannabinoid CBI receptors... [Pg.323]

The predominant action of cannabinoid receptor agonists on the GI tract is an inhibitory effect on gastrointestinal motility, reminiscent of the neuromodulatory response to presynaptic p-opioid receptor or 02 -adrenoceptor activation of cholinergic, postganglionic parasympathetic neurons. The mechanisms underlying this effect have been studied chiefly in the GI tract of small rodents, but also in man and the pig. Here we shall review the findings of studies carried out in vitro (Sect. 3.1, below) and in vivo (Sect. 3.2). [Pg.577]

Chronic treatment with cannabinoids can induce a state of tolerance to their inhibitory effects in the gastrointestinal tract. Studies of this phenomenon have been performed predominantly with pieces of tissue excised from chronically treated animals (ex vivo) or on isolated tissues pretreated in vitro with a cannabinoid receptor agonist. These investigations were comprehensively reviewed by Pertwee (2001) and will be summarised here. [Pg.583]

There is now substantial evidence for the presence of endocannabinoid and endovanilloid systems in the GI tract. The anti-inflammatory, anticancer, antiulcero-genic and antiemetic responses to CBi receptor activation holds promise for the future management of gastrointestinal diseases. Thus, exploitation of the endocannabinoid system by facilitation at sites of endocannabinoid activity by preventing cellular re-uptake or reducing EC degradation may enhance beneficial endocannabinoid effects without the psychotropic side-effects found with systemic administration of exogenous cannabinoids. Manipulation of the endocannabinoid... [Pg.591]

Coutts AA (2004) Cannabinoid receptor activation and the endocannabinoid system in the gastrointestinal tract. Curr Neuropharmacol 2 91-102... [Pg.593]

Di Carlo G, Izzo AA (2003) Cannabinoids for gastrointestinal diseases potential therapeutic applications. Expert Opin Investig Drugs 12 39-49... [Pg.593]

Izzo AA, Pinto L, BorreUi F, Capasso R, Mascolo N, Capasso F (2000b) Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oU. Br J Pharmacol 129 1627-1632... [Pg.594]

Izzo AA, Mascolo N, Capasso F (2001 c) The gastrointestinal pharmacology of cannabinoids. Curr Opin Pharmacol 1 597-603... [Pg.595]

Landi M, Croci T, Rinaldi-Carmona M, Maffrand JP, Le Fur G, Manara L (2002) Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CBI receptors. Eur J Pharmacol 450 77-83... [Pg.595]

Izzo, A.A., Pinto, L., Borrelli, E, Capasso, R., Mascolo, N., and Capasso, F (2000) Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states and during diarrhea induced by croton oil, Br. J. Pharmacol. 129 1027-1032. [Pg.416]

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