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Candidate-gene strategy

Nicotine addiction is very complex and pharmacological evidence alongside structure and function analysis of candidate genes may clarify the mechanisms involved. The challenge will be to translate known genetic variation into therapeutic strategies to reduce the prevalence of smoking in the population. [Pg.452]

As stated above, the ultimate mechanism of action of the antidepressant and anxiolytic effects of antidepressant drugs have not been fully elucidated yet. It is therefore necessary to identify novel candidate genes using unbiased genome-wide strategies. [Pg.538]

Strategies to Identify Pharmacogenomic Biomarkers Candidate Gene, Pathway-Based, and Genome-Wide Approaches... [Pg.353]

In another example, comparative genome comparison was combined with constraints-based flux analysis to develop metabolic engineering strategies for the enhanced production of succinic acid by E. coli [1, 39, 40]. Comparative genome analysis of E. coli and M. succiniciproducens predicted five candidate genes to be manipulated for overproducing succinic acid in E. coli. Then, constraints-based flux... [Pg.6]

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See also in sourсe #XX -- [ Pg.14 ]



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