Candida ring-opening copolymerization

Scheme 4.24 Ring-opening copolymerization of cyclic thioester and cyclic ester using Candida antarctica lipase.

Poly(TMC-co-ethylene ethyl phosphate) was prepared by ring-opening copolymerization catalyzed by lipase enzymes (pancreas lipase, PPL and Candida rugosa lipase, CL) as catalysts in bulk at 100 °C with molecular weight (Mn) from 3200 to 10 200. Degradation experiments showed that introducing phosphate groups into the TMC chain increases the hydrolysis rate of the copolymer. 

Enzymatic ring-opening copolymerization of structures 77 and 11 was performed in bulk at 100 °C using porcine pancreas lipase and/or Candida rugosa lipase as catalysts. 

For example Kumar, A., and Gross, R. A., 2000, Candida antarctica Lipase B-Catalyzed Transesterification New Synthetic Routes to Copolyesters. J. Am. Chem. Soc. 122 11767-11770 Kumar, A., and Gross, R. A., 2000, Candida antartica lipase B catalyzed polycaprolactone synthesis effects of organic media and temperature. Biomacromolecules 1 133-138 Kobayashi, S, Uyama, H., Namekawa, S., and Hayakawa, H., 1998, Enzymic Ring-Opening Polymerization and Copolymerization of 8-Octanolide by Lipase Catalyst. Macromolecules 31 5655. 

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