Polycaprolactone catalyzed

Mukaiyama, M., Hayakawa, M., Oouchi, K., Mitani, M., and Yamada, T., Preparation of Narrow Polydispersity Polycaprolactone Catalyzed by Cationic Zirconocene Complexes. 1995, Chem. Lett.,737 pp... 

Commercial end functional polymers have been converted to alkoxyamincs and used to prepare PKO-Worri-PS.040 The hydroxyl group of alkoxyamine 284 was used to initiate ring-opening polymerization of caprolactonc catalyzed by aluminum tris(isopropoxide) and the product subsequently was used to initiate S polymerization by NMP thus forming polycaprolactone-Wodr- P8.641 The alternate strategy of forming PS by NMP and using the hydroxyl chain end of the product to initiate polymerization of caprolactonc was also used. 

Immobilized CALB has frequently been applied in the literature as a catalyst for polymerization of aliphatic polyesters, polycarbonates, polyurethanes and their copolymers. In the present work on CALB catalyzed polymerization, the ring opening of e-caprolactone to polycaprolactone was selected as the model polymerization reaction (Figure 3.3). This model reaction has been well established in the literature [24-27] as an example of a polymerization reaction that can be successfully catalyzed by immobilized lipases (see also Chapter 4). Polymer synthesis and characterization was performed in four steps (i) polymerization (ii) separation (iii) purification and (iv) characterization. 

Kumar, A., and Gross, R.A. (2000) Candida antartica lipase B catalyzed polycaprolactone synthesis effects of organic media and temperature. Biomacromolecules, 1, 133-138. 

PCL - The polycaprolactone is derived from 8-caprolactone by ring-opening polymerization catalyzed by transition metal compounds. Toldwa and Suzuki (Tokiwa and Suzuki, 1977) have reported that PCL can be enzymatically degraded in presence of fungi and the biodegradation process has been discussed by Bastioli (Bastioli, 1998). 

For example Kumar, A., and Gross, R. A., 2000, Candida antarctica Lipase B-Catalyzed Transesterification New Synthetic Routes to Copolyesters. J. Am. Chem. Soc. 122 11767-11770 Kumar, A., and Gross, R. A., 2000, Candida antartica lipase B catalyzed polycaprolactone synthesis effects of organic media and temperature. Biomacromolecules 1 133-138 Kobayashi, S, Uyama, H., Namekawa, S., and Hayakawa, H., 1998, Enzymic Ring-Opening Polymerization and Copolymerization of 8-Octanolide by Lipase Catalyst. Macromolecules 31 5655. 

Kondo R, Toshima K, Matsumara S (2002), Lipase-catalyzed selective transformation of polycaprolactone into cyclic dicaprolactone and its repolymerisation in supercritical carbon dioxide , Macromol. Biosci., 2, 267-271. 

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