Candida albicans, antimicrobial agents

Georgopapadakou, N.H. and Bertasso, A. (1992) Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrobial Agents and Chemotherapy, 36, 1779-1781. 

Mirels, L.F., and Stevens, D.A. (2002) Resistance mechanisms in dinical isolates of Candida albicans. Antimicrobial Agents and Chemotherapy, 46, 1704-1713. 

Silver, P.M., Little, J.T., Choiniere, J., and White, T.C. (2005) Drug-induced regulation of the MDR 3 promoter in Candida albicans. Antimicrobial Agents and Chemotherapy, 49, 2785—2792. 

Candida albicans. Antimicrob Agents Chemother 30(3) 499-501 Ahmad JI (1996) Garlic - a panacea for health and good taste. Nutr Food Sci 1 32-35 Aires A, Mota VR, Saavedra MJ et al (2009) The antimicrobial effects of glucosinolates and their respective hydrolysis products on bacteria isolated from human intestimil tract. J Appl Microbiol... 

Only three constituents have been reported from Broussonetia zeylanica, all by a group at the University of Peradeniya in Sri Lanka [89-91]. A major alkaloid, 8-hydroxyquinoline-4-carbaldehyde (55), was identified as an antimicrobial agent active against Staphyllococus aureus and Candida albicans (the levels of activity were not specified) [89] and then two minor compounds, 3,4 -dihydroxy-2,3 -bipyridine (56) and 3,4-bis(8-hydroxyquinolin-4-yl)-y-butyrolactone (broussonetine, 57), were reported, Fig. (10) [90,91]. However, the structure of 3,4 -dihydroxy-2,3 -bipyridine (56) was revised to 8-hydroxyquinoline-4-carbaldehyde oxime (58) by synthesis [92,93]. Also, it was noted that an artefactual origin of this oxime (58) could not be ruled out due to the presence of the corresponding aldehyde (55) [93]. 

Antimicrobial agent Aspergillus niger Trichophyton mentagrophytes Candida albicans... 

Sanglard, D., Ischer, F., Monod, M., and Bille, J. (1996) Susceptibilities of Candida albicans multidrug transporter mutants to various antiftmgal agents and other metabolic inhibitors. Antimicrobial Agents and Chemotherapy, 40, 2300-2305. 

MacPherson, S., Akache, B., Weber, S., De Deken, X., Raymond, M., and Turcotte, B. (2005) Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. Antimicrobial Agents and Chemotherapy, 49, 1745-1752. 

Niimi, K., Maki, K., Ikeda, F., Holmes, A.R., Lamping, E., Niimi, M., Monk, B.C., and Cannon, R.D. (2006) Overexpression of Candida albicans CDRl, CDR2, or MDRl does not produce signifleant changes in echinocandin susceptibility. Antimicrobial Agents and Chemotherapy, 50, 1148-1155. 

Ben-Yaacoy R., Knoller, S., Caldwell, G.A., Becker, J.M., and Koltin, Y. (1994) Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene. Antimicrobial Agents and Chemotherapy, 38, 648-652. 

Goldway, M., Teff, D., Schmidt, R., Oppenheim, A.B., and Koltin, Y. (1995) Multidrug resistance in Candida albicans disruption of the BENr gene. Antimicrobial Agents and Chemotherapy, 39, 422-426. 

Cheng, S., Clancy, C.J., Nguyen, KT, Clapp, W, and Nguyen, M.H. (2007) A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDRl and has diminished susceptibility to fluconazole and voriconazole. Antimicrobial Agents and Chemotherapy, 51, 1855-1858. 

Vinjamuri et al. showed that radiolabeled ciprofloxacin (Infecton), a fluoroquinolone antimicrobial agent that binds to the DNA gyrase in all dividing bacteria, could successfully discriminate between bacterial infections and sterile inflammations [152]. A further example of this class of tracers is Tc-labeled fluconazole. Lu-petti et al. showed that Tc-fluconazole is a very good marker for Candida albicans ... 

Harriott MM, Noverr MC. Candida albicans and Staphylococcus aureus form polymicrobial bioflhns effects on antimicrobial resistance. Antimicrob Agents Chemother September 2009 53(9) 3914-22. 

---