Canderel - Aspartame

Canderel aspartame, candesartan candesartancilexetil. eandesartan cilexetil (Amias ) is a benzimidazole-carboxylic acid derivative, an (AT,) ANGIOTENSIN RECEPTOR ANTAGONIST, used as an antihypertensive. It is an ethyl ester prodrug of candesartan (CV 11974). It has experimental renal protective effects. 

Most of the food and feed additives are commoditized. This is also the case for the artificial sweeteners. The main products are Saccharin (550), Aspartame (Canderel, 200), Acesulfam K (Sunnett, 200), and Cyclamate (35). The figures in brackets are the sweetness intensity, whereby sucrose = 1. Sucra-lose, discovered in the 1980s by Tate Lyle, now taken over by Johnson Johnson s formidable marketing machine, is enjoying a revival as Spenda. 

Aspartame is an intense sweetener first discovered in 1965 by J. Schlatter it is available under the brand names of Nutrasweet , Equal , and Canderel . Chemically, aspartame is N-L-a-aspartyl-L-phenylalanine methyl ester (Fig. 1), withamolecularformulaofC14H 805N2 (MW = 294.30). It is a white, odorless, crystalline powder. It is slightly soluble in water and sparingly soluble in alcohol. The solubility increases as the pH is lowered (2,6,57). It has 100-200 times the sweetness of sucrose and exhibits a sweet, clean taste and a sweetness profile similar to that of sucrose, without bitter or metallic aftertaste (Table 1). However, it displays a slow onset of sweetness coupled with lingering sweet taste. It extends and intensifies tastes and enhances fruit flavors. Aspartame exhibits synergism, a superior taste profile, and improved stability when used with other sweeteners (1,4,14,55,75). 

Aspartyl phenylalanine-l-methyl ester, better known as aspartame, is an artificial sweetener with a worldwide production exceeding 15 000 tpa. It is marketed under the trade names Nutrasweet, Canderel, and Equal. This dipeptide, made of aspartic... 

Aspartame. [Nutrasweet]. (3-amino-n-(a-carboxyphenethyl)succinamic acid n-methyl ester, stereoisomer aspartylphenylalanine methyl ester n-l-a-aspartyl-l-phenylalanine 1-methyl ester canderel dipeptide sweetener Equal (TM) methyl aspartylphenylalanate 1-methyl n-l-a-as-partyl-l-phenylalanine Nutrasweet (TM) sweet dipeptide). C14H18N205. 

Amino-N-(a-methoxycarbonylphenethyl) succinamic acid 3-Amino-N-(a-carboxyphenethyl)succinamic acid N-methyl ester APM Asp-phe-ome Aspartam Aspartame Aspartame, L,L-a- Aspartamo Aspartamum Aspartylphenylalanine methyl ester L-Aspartyl-L-phenylalanine methyl ester Canderel CCRiS 5456 DIpeptide sweetener EINECS 245-261-3 Equal HSDB 3915 Methyl aspartylphenylalanate Methyl L-aspartyl-L-phenylalanine Methyl L-a-aspartyl-L-phenylalanate Methyl N-L-a-aspartyl-L-phenylalaninate 1-Methyl N-L-a-aspartyl-L-phenylalanate Nutrasweet L-Phenylalanine, L-a-aspartyl-, 2-methyl ester L-Phenylalanine, N-L-a-aspartyl-, 1-methyl ester SC 18862 Succinamic acid, 3-amino-N-(a-carboxyphenethyl)-, N-methyl ester, Sweet dipeptide Tri-sweet, A sweetening agent Crystals mp = 246-247° [a]8 = -2,3° (IN HCI). Searte 6.D. Co. 

Aspartame is a relatively new sweetener which is readily available and known commercially as Canderel. It is the methyl ester of the dipeptide L-aspartyl-L-phenylalanine and has a natural sugar-like taste. It is about 200 times as sweet as sucrose and, in addition, has flavour-enhancing... 

Aspartame, a nonnutritive sweetener marketed under such trade names as Equal, NutraSweet, and Canderel, is the methyl ester of a simple dipeptide, Asp-Phe-OCHs. 

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