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Cancer sirtuin

Together these findings predict a major role for sirtuin modulators, both activators and inhibitors, in the treatment of cancer. [Pg.234]

Ashraf N., Zino, S., Macintyre, A., Kingsmore, D., Payne, A.P., George, WD. and Shiels, P.G. (2006) Altered sirtuin expression is associated with nodepositive breast cancer. British Journal of Gancer, 95, 1056-1061. [Pg.242]

Seven human subtypes of sirtuins have been identified. SIRTl deacetylates proteins such as p53 or BCL6. SIRT2 deacetylates tubulin and its inhibition results in neuroprotection. Elevated levels of S1RT3 have been observed in breast cancer. A number of sirtuins promote extended lifespan in various organisms. ... [Pg.164]

Mammalian sirtuins (SIRTs, silent information regulator transcript) were identified as conserved structural homologues to the yeast silent information regulator protein (Sir2), which has been shown to mediate longevity under calorie restriction conditions. The increased lifespan associated with calorie restriction in general has been attributed to reduced rates of cancer, diabetes, inflammation, and cardiovascular... [Pg.202]

See other pages where Cancer sirtuin is mentioned: [Pg.102]    [Pg.247]    [Pg.345]    [Pg.345]    [Pg.70]    [Pg.383]    [Pg.24]    [Pg.230]    [Pg.232]    [Pg.233]    [Pg.233]    [Pg.234]    [Pg.89]    [Pg.467]    [Pg.406]    [Pg.16]    [Pg.27]    [Pg.406]    [Pg.257]    [Pg.130]    [Pg.339]    [Pg.2276]    [Pg.137]    [Pg.138]    [Pg.139]    [Pg.145]    [Pg.150]    [Pg.482]    [Pg.324]    [Pg.326]    [Pg.199]   
See also in sourсe #XX -- [ Pg.232 ]



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