Cancer malignant tumours

A-nitrosodimethylamine (NDMA). A-Nitrosomorpholine (NMOR) is also produced in this process, but the origin of this pollutant is unknown. Samples collected from different tanneries showed airborne nitrosamine contamination ranging from 0.05-47 Xg/m3 NDMA (mean 3.4 pg/m3) and 0.05-2.0 pg/m3 NMOR (mean 0.2 pg/m3)64. Studies have indicated the possible risk of nasal cancer to workers exposed to NDMA at a daily exposure level of 440 pg NDMA/person/day and 20 pg NMOR/person/day65. Animals exposed to long-term inhalation of NDMA were found to have formed malignant tumours of mainly the liver and kidney66. 

Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T (2005). Opinion migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev CancerS 744-749. 

Remarkable claims have been made for violet leaves in the treatment of malignant tumours. The case of Lady Margaret Marsham, of Maidstone, was reported in the Daily Mail for November 14th, 1901. This lady, suffering from cancer of the throat, used an infusion, which was left to stand for twelve hours, of a handful of fresh violet leaves to a pint of... 

II 000 cm-1). Nevertheless, the photophysics of lanthanide porphyrinates is attractive because it could be of great help in medicine. For instance, hematoporphyrin derivatives are known to accumulate in malignant tumours and are used in medical diagnosis and photodynamic therapy of cancer. It is noteworthy that the Yb(III) complex with meso-tetra(3-pyridyl)porphyrin displays a substantial quantum yield (1.4%) when inserted into micelles formed by the non-ionic surfactant Triton X-100, a medium that can be considered as a model for biological tissues. 

Saric M, Curin K. 1996. Malignant tumours of the gastrointestinal tract in an area with an asbestos-cementplant. Cancer Lett 103 191-199. 

The term carcinogen denotes a chemical substance or a mixture of chemical substances which induce cancer or increase its incidence. Substances which have induced benign and malignant tumours in well performed experimental studies on animals are considered also to be presumed or suspected human carcinogens unless there is strong evidence that the mechanism of tumour formation is not relevant for humans. 

Die very first publication on biofluid NMR spectroscopy was concerned with the detection of cancer. In it Ohsaka et al. reported that 100 MHz NMR spectra of human blood serum showed high lactate levels for patients with malignant tumours. Diis method has not been widely used due to two factors (i) lactate is not 100% NMR visible in blood serum or plasma and (ii) variability in lactate levels due to many factors other than cancer. - However, Nagasawa et al. have also reported analogous results for lactate elevation in the urine from mice with mammary tumours. 

Ehrlich tumours are poorly differentiated malignant tumours (originally a breast carcinoma in a mouse), which grow in solid and ascetic forms. HeLa cells are a cell line developed from cervical cancer of a woman ( enriette Lacks), who died from that cancer in 1951. 

Cancer is the unrestrained, malignant proliferation of a somatic cell. The result is a tumour which is a progressively growing mass of abnormal tissue. The term cancer usually applies to malignant tumours rather than benign ones as the latter do not normally invade healthy tissue. A characteristic of cancer... 

Dactinomycin, or actinomycin D as it was called when first introduced, has shown striking curative properties in Wilms s tumour of the kidney which forms a high proportion of all malignant tumours in children. Under its influence, even pulmonary metastases caused by this tumour regress (Farber and Mitus, 1968). Forms of cancer requiring longer treatment are not suitable for this drug, which has only moderate selectivity. 

Table 6.3. Staging system for endometrial cancer (UICC, TNM Classification of Malignant Tumours, FIGO Staging System)...

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