Games Cancer

Consider the following Cancer Game, which makes use of a computer enzyme to create complicated genetic sequences. Amazing complexity arises in just a few gen-... 

Various researchers have studied the Cancer Game, including David Epstein, a member of the Department of Information and Computer Science at the University of California, Irvine. He notes that the starting character repeats every four generations. He also believes that the after-split sequence lengths, starting in generation 6, can be described by the recurrences... 

Chapter 15 Creating Life Using the Cancer Game... 

Compute Cancer Game Sequence (CONTINUED) / / CLEAV splits sequence at T-T / scur-j ... 

E. Dudley, F. Lemiere, W. Van Dongen, J.I. Langridge, S. El-Sharkawi, D.E. Games, E.L. Esmans, R.P. Newton, Analysis of urinary nucleosides. III. Identification of 5 -deoxycytidine in urine of a patient with head and neck cancer. Rapid Commun. Mass Spectrom., 17(2003) 1132. 

In molecular devices for medical application, typically speaking the principle actor is only one component, the payload, namely the repair equipment or the drug. The rest of the structure is to get the payload material where it needs to be, from gut to blood, from blood to tissue, and from cell surface to cellular compartment, and maybe into the chromosome. There is effectively a series of distinct keys to be used, a bit like those you must win to get you to your goal in a computer-based adventure game. Most such structures functioning as elaborate antiobiotics are injected into the bloodstream, and they recognize, bind to, and possibly enter an infecting bacterium, parasite, or cancer cell. Those that enter the cell also may need to have features that allow them to... 

Di Carlo E, lezzi M, Pannellini T, Zaccardi F, Modesti A, Forni G, Musiani P Neutrophils in anti-cancer immunological strategies Old players in new games. J Hematother Stem Cell Res 2001 10 739-748. 

Efficacy is not the only game safety (unwanted side effects and their consequences) and the nature of the treated disease are also major factors. Even mild side effects cause concern if the treated illness is not severe. On the other hand, serious side effects can still be acceptable in a medicine curing a life threatening disease. The tolerance limit for side effects is very different for cancer drags and antacids. 

Habano W, Game T, Sugai T, Otsuka K, Wakabayashi G, Ozawa S (2009) CYPIBI, but not CYPlAl, is downregulated by promoter methylation in colorectal cancers. Int J Oncol 34 1085-1091... 

Lash TL, Cronin-Fenton D, Ahem TP, Rosenberg CL, Lunetta KL, Silliman RA, Hamilton-Dutoit S, Game JP, Ewertz M, Sorensen HT, Pedersen L. Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen. Acta Oncol 2010 49 305-12. 

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