Cancer anticancer agent

Minko T et al (2006) New generation of liposomal drugs for cancer. Anticancer Agents Med Chem 6 537-552... 

It is emphasized in NCFs own definition of the word, that chemoprevention is not directed at curing cancer after the cancer has developed. Its purpose is strictly preventive, although the theories and therapies may be applicable even to developing cancers. Anticancer agents may also be useful in chemoprevention. 

Inositols, ie, hexaliydrobenzenehexols, are sugars that have received increasing study and are useful in the treatment of a wide variety of human disorders, including vascular disease, cancer, cirrhosis of the Hver, frostbite, and muscular dystrophy (269). Myoinositol esters prepared by reaction with lower fatty acid anhydrides are useful as Hver medicines and nonionic surfactants the aluminum and ammonium salts of inositol hexasulfate are useful anticancer agents (270). Tetraarjloxybenzoquinones are intermediates in the preparation of dioxazine dyes (266,271). The synthesis of hexakis(aryloxy)benzenes has also beenpubUshed (272). 

Camptothecin was discovered as an active anticancer drug isolated from the bark of Camptotheca acuminata. The anticancer activity of camptothecin was discovered in the 1960s by the National Cancer Institute (NCI) as part of a systematic effort to screen for novel anticancer agents derived from natural products. Monroe Wall and Mansuhk Wani identified the chemical structure of camptothecin. They also identified the chemical structure of taxol, again under the auspices of the NCI. Susan Hoiwitz was contracted by the NCI to elucidate the anticancer mechanisms of camptothecin. She found in the early 1970s that camptothecin induced DNA breaks and attested DNA and RNA synthesis. However, it is approximately 12 years later, only after DNA topo-isomerase I (Topi) had been identified in human cells, that Leroy Liu and his coworkers found that Topi was the cellular target of camptothecin [reviewed in [1]. 

Brown JM, Wouters BG (1999) Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 59 1391-1399... 

Breast cancer resistance protein (BCRP) is another ATP-dependent efflux transporter that confers resistance to a variety of anticancer agents, including... 

Hasinoff, B. B. Wu, X. Yalowich, J. C. Goodfellow, V. Laufer, R. S. Adedayo, O. Dmitrienko, G. I. Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents antiproliferative and cell cycle effects. Anti-Cancer Drugs 2006, 17, 825-837. 

T. Konno, Targeting anticancer chemotherapy for primary and secondary liver cancer using arterially administered oily anticancer agents, in Cancer Chemotherapy Challenges for the Future (K. Kimura, ed.), Excerpta Medica, Tokyo. 1987, p. 287. 

Pt cw-[Pt(amine)2X2] Anticancer agents Platinol Paraplatin Eloxatine Testicular, ovarian, colon cancers... 

Farrell, N. P. Polynuclear Charged Platinum Compounds as a New Class of Anticancer Agents Toward a New Paradigm In Platinum-Based Drugs in Cancer Therapy, Kelland, L. R. and Farrell, N. P., Ed. Humana Press, 2000, pp 321-338. 

Matsumura Y, Kataoka K (2009) Preclinical and clinical studies of anticancer agent-incorporating polymer micelles. Cancer Sci 100 572-579... 

These amino acid and protein binding results might account for the low toxic side effects of this class of anticancer agents (72). On the other hand, the relatively weak binding to amino acids and proteins could perhaps aid in transport and delivery of active species to cancer cells prior to binding to DNA or RNA (75). 

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