Campholic acid

When bomeol or camphor is heated with solid potassium hydroxide to 250-280 °C, ring cleavage of the bicyclic system occurs and the product, campholic acid 68, can be isolated in high yield65-67. Thus, (-)-borneol gives ( + )-campholic acid [( + )-68], which has been used as the hydroxamic acid derivative as a chiral ligand for a vanadium catalyst in the enantioselective epoxidation of allylic alcohols (Section D.4.5.2.4.). 

Querbet, Compt. rend., 1909,148,98,721 P-Campholic Acid (2 2 8. Z-TetramethyU eydopeintaneal-carboxylic acid)... 

The reaction proceeds quite smoothly even with acids in which the carboxyl group is inert to many reagents. Thus, carboxyl groups attached to tertiary carbon atoms as in campholic acid (VII), podo-carpic acid (VIII), and the isobutyric acid derivative (IX) are replaced by amino groups in good yields. 

Calacone, T16 Calamenene, T16 Calarane, T26 Calciferol, T48 Calcorene, T16 Caldariomycin, Y16 Callicarpone, T33 Callitrisic acid, T33 Calodendrolide, T16 Calycanthidine, K26 Calycanthine, K26 Calycotomine, K2 Camphene, Til Camphenilone, Til Campherenone, T28 Campholic acid, A36 Camphonanic acid, T12 Camphor, Til cw-camphoric acid, T12 Camphoronic acid, T12 Camphorquinone, T12 Camphorsulphonic acids, T11-12 Camptothecin, K29 Canallinin, Z8 Canaric acid, T43 Cancentrine, K2 ... 

Euphorbia hirta L. Da Fei Yang Cao (Asthma herb) (stem) Camphol, leucocyanidol, quercitol, quercitrin, rhamnose, euphorbon, chlorophenolic acid, taraxerol, taraxerone, gallic acid.50 For asthma, bronchitis, externally for athlete s foot. 

Euphorbia humifusa Willd. Deng Qing Cao (Wolf s milk) (aerial part) Camphol, euphorbon, gallic acid.48 Antibacterial, detoxicant against diphtheria toxin. 

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