Calcium phosphate-polymer nanocomposites

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Figure 1. TEM image of the calcium phosphate nanoparticles (PEO CaCI, (a) 2 1, (b) 4 1, (c) 5 1). Preparation of Nanocomposite Polymer Electrolytes...

Weickmann, H., Gurr, M., Meincke, O., Thomann, R., and Miilhaupt, R., 2010. A versatile solvent-free one-pot route to polymer nanocomposites and the in situ formation of calcium phosphate/layered silicate hybrid nanoparticles. Advanced Functional Materials 20 1778-86. 

Schneider OD, Stepuk A, Mohn D, Luechinger NA, Feldman K, Stark WJ. Light-curahle polymer/calcium phosphate nanocomposite glue for hone defect treatment. Acta Biomater 2010 6(7) 2704-10. 

In vivo bio-mineralization, the main process involved in the formation of bone tissues, has been exploited in another facile, bottom-up, self-assembling method for processing nanostructured, calcium phosphate (CaP) NPs (Loomba and Sekhon, 2015) and CaP/polymer hybrids (eg, poly(ethylene glycol)-(>-polylactide (PEG-PLA)ZCaP nanocomposites, poly(acrylic acid-fc-isoprene)/CaP hybrid nanocapsules, poly(Af-isopropylacrylamide) (PNlPAAm)/CaP) (Fig. 2.8), the later possessing dual (pH- and thermal-) responsive control over the (drug) release process (Shi et al., 2012). 

Fig. 2.8 Illustration of mineralization-mediated nanocomposites formation. CaP-based nanocrystalites nucleate on the outer surface of PNIPAAm microgels (A) and at near-surface regions of the PAA polymer nanostructures (B). CaP, calcium phosphate PNIPAAm, poly(A-isopropylacrylamide) and PAA, polyacrylamide.

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