Calcium channels pharmacology

Catterall, W. A., Perez-Reyes, E., Snutch, T. P., Sc Striessnig, J. (2005). International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacological Reviews, 57(4), 411—425. 

Opiates iateract with three principal classes of opioid GPCRs )J.-selective for the endorphiQS,5-selective for enkephalins, and K-selective for dynorphias (51). AU. three receptors have been cloned. Each inhibits adenylate cyclase, can activate potassium channels, and inhibit A/-type calcium channels. The classical opiates, morphine and its antagonists naloxone (144) and naltrexone (145), have moderate selectivity for the. -receptor. Pharmacological evidence suggests that there are two subtypes of the. -receptor and three subtypes each of the 5- and K-receptor. An s-opiate receptor may also exist. 

Pharmacological intervention NSAIDs, local anesthetics, opioid analgesics, sodium-channel blockers Opioid analgesics, NSAIDs, calcium-channel blockers ... 

Other drugs such as the neuroleptic, haloperidol, inhibit the induction of hsp70 mRNA in rodent neurons (Sharp et al.. 1992). Although this observation needs to be confirmed in the human population, it raises the possibility that an age-dependent defect in the production of HS proteins is exacerbated by a drug which is commonly used in demented elderly patients. The potential for certain pharmacologic agents to inhibit the HS response could increase the risk for untoward effects of atherosclerosis and hypoxia. A similar concern may be raised with certain calcium channel blockers which also have been found to reduce the synthesis of HS proteins in cardiac myocytes (Low-Friedrich and Schoeppe, 1991). 

After the study of pharmaceutical sciences in Frankfurt/Main 1 joined the Department of Clinical Physiology at the Heinrich-Heine-Universitat Diisseldorf to start my PhD work dedicated to pharmacological studies of the calcium channel blocker verapamil under the supervision of Raimund Kaufmann. He was a very liberal scientific teacher and he aUowed me to fine-tune the contents of my PhD work according to my personal preferences. 

The pharmacological profile of amiodarone is extremely complex. On acute exposure the compound slows conduction (indicative of Class I elec-trophysiological activity) [17], exhibits both a- and y9-adrenergic antagonism [18], and may have an effect on calcium channels [19]. The Class III elec-trophysiological activity is generally not manifest on acute exposure but may take several days to weeks to reach maximal effect in patients [20,21]. 

Q22 Pharmacological effects of calcium-channel blocking agents may... 

Pharmacology The calcium channel blockers share the ability to inhibit movement of calcium ions across the cell membrane. The effects on the cardiovascular system include depression of mechanical contraction of myocardial and smooth muscle and depression of both impulse formation (automaticity) and conduction velocity. 

Pharmacology Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in CNS tissues. Although the... 

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