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Calcium channel blockers antianginals

Diltiazem MMD terolemic) Calcium channel blocker (antianginal) 1980 1969 Breakthrough drug Novel structural class... [Pg.138]

Antianginal agents, 5 107-135, 110-lllt, 118-120t, 124-124t arylalkylamines and benzothiazepins (calcium channel blockers),... [Pg.61]

In addition to being used as antianginal and antiarrhythmic agents, calcium channel blockers are used to treat weak and moderate hypertension. These drugs prevent calcium ions from entering into the smooth muscle cells of peripheral vessels, and they cause relaxation of peripheral vessels, which leads to lowering of arterial blood pressure. In clinically used doses, calcium channel blockers relax smooth musculature of arteries and have little effect on veins. In doses that relax smooth musculature, calcium channel blockers have relatively little effect on cardiac contractility. [Pg.303]

In addition to their antianginal (see Chapter 12) and antiarrhythmic effects (see Chapter 14), calcium channel blockers also reduce peripheral resistance and blood pressure. The mechanism of action in hypertension (and, in part, in angina) is inhibition of calcium influx into arterial smooth muscle cells. [Pg.237]

Calcium channel blockers also cause some degree of systemic vasodilation, and some of their antianginal effects may be related to a decrease in myocardial oxygen demand caused by a decrease in cardiac preload and afterload that is, they may exert some of their... [Pg.311]

Calcium channel blockers [dihydropyridine group] -ipine Nifedipine, nicardipine Antihypertensive (21), antianginal (22)... [Pg.657]

Four categories of calcium channel blockers can be defined based on their chemical structures and actions diphenylalkylamines, benzothiazepines, dihydropyridines, and bepridil. Both diphenylalkylamines (verapamil) and benzothiazepines (diltiazem) exhibit effects on both cardiac and vascular tissue. With specificity for the heart tissue, these two types of calcium channel blockers can slow conduction through the AV node and are useful in treating arrhythmias. The dihydropyridines (nifedipine is the prototypical agent) are more potent peripheral and coronary artery vasodilators. They do not affect cardiac conduction, but can dilate coronary arteries. They are particularly useful as antianginal agents. Bepridil is unique in that it blocks both fast sodium channels and calcium channels in the heart. All calcium channel blockers, except nimodipine and bepridil, are effective in treating HTN. [Pg.21]

Feldene piroxicam. felodipine [ban, inn, usan] (Plendil etc.) is a dihydropyridine calcium-channel blocker with VASODILATOR properties, which can be used in ANTIHYPERTENSIVE therapy and antianginal prophylaxis, felypressin [ban, inn, usan] ([Phe Lys ]vasopressin phelypressin PLV2 Octapressin Octopressin ) is a synthetic analogue of vasopressin. It is a VASOCONSTRICTOR and is incorporated into LOCAL ANAESTHETIC preparations to prolong their duration of action. (It is a constituent with prilocaine of Citanest with Octapressin .)... [Pg.119]

Nirolex dextromethorphan, nisoldipine [ban, inn, jan, usan] (Sular Syscor ) is a dihydropyridine CALCIUM-CHANNEL blocker with coronary VASODILATOR properties, which can be used as an oral ANTIHYPERTENSIVE and ANTIANGINAL. [Pg.199]

P,-selectivity. It can be used in HEART FAILURE TREATMENT, prenalterol hydrochloride prenalterol. prenylamine [ban, inn, usan] is a phenylpropylamine. a coronary VASODILATOR its use in antianginal treatment has diminished due to toxicity. It depletes catecholamines in the heart and has some CALCIUM-CHANNEL BLOCKER activity. Prepadine dothiepin. [Pg.231]

Calcium channel blockers (see 19.9 Antianginals) dilate coronary arteries and arterioles, and decrease total peripheral vascular resistance. [Pg.298]

Cayl channels (L-type) are targets of calcium-channel blockers or calcium antagonists which decrease the influx of Ca + in cardiac and smooth muscle vascular cells dihy-dropyridines (nifedipine and analogs), phenylalkylamines (verapamil) and benzothiazepines (diltiazem), widely used as antihypertensive, antianginal and antiarrhythmic drugs. Cayl openers, like Bay K 8644, have been synthesized but have not found any therapeutic interest. [Pg.91]

Diltiazem malate MK-793. Calcium channel blocker with coronary vasodilating xtivity. Class IV antiarrhythmic. Antianginal antihypertensive class IV antiarrhythmic. Bristol Myers Squibb Pharm. Ltd. Forest Pharm. Inc. Fldchst AG (USA) Lemmon Co. Rhdne-Poulenc Rarer Pharm. Inc. [Pg.223]

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See also in sourсe #XX -- [ Pg.31 , Pg.311 , Pg.314 , Pg.315 ]



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