Calcitonin penetration enhancers

Finally, it should be noted that during the last decade both weakly crosslinked poly(acrylic acid) derivatives and chitosan derivatives were described as safe penetration enhancers for hydrophilic compounds especially as they can trigger mechanisms of tight junction opening of mucosal tissues and did not show acute toxicity. Poly(acrylic acid) derivatives were shown to have excellent mucoadhesive properties and can inhibit the activity of gut enzymes, such as trypsin, chymo-trypsin, and carboxypepsidases. Chitosan salts and Ni-trimethylchitosan chloride revealed to be potential absorption enhancers for nasal absorption of calcitonin and insulin and for the intestinal absorption of buserilin.f ... 

Electroporation has been combined with iontophoresis to enhance the penetration of peptides such as vasopressin, neurotensin, calcitonin, and LHRH, as well as other compounds such as defibrase and dextran sulfate [44-49]. However, failures have also been reported [50,51],... 

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