Cadmium monoesters

STEARIC ACID, CADMIUM SALT see OATOOO STEARIC ACID, LEAD SALT see LDXOOO STEARIC ACID, LITHIUM SALT see LHQIOO STEARIC ACID, MONOESTER with ETHYLENE GLYCOL see EJM500... 

Metalloenzyme-catalyzed phosphoric ester hydrolysis can be illustrated by alkaline phosphatase, by far the most-investigated enzyme of this class. The protein is a dimer of 94 kDa containing two zinc(II) and one magnesium(II) ions per monomer, and catalyzes, rather unspecifically, the hydrolysis of a variety of phosphate monoesters as well as transphosphorylation reactions. The x-ray structure at 2.8 A resolution obtained on a derivative in which all the native metal ions were replaced by cadmium(II) reveals three metals in each subunit. 

Certain dipositive metal ions not only accelerate the hydrolysis of ATP, as mentioned above, but also assist in the transfer of a phosphoryl group from one molecule to another. Such a nonenzymatic transphosphorylation takes place between ATP and an orthophosphate ion or its monoester in the presence of calcium(II), cadmium(II), and manganese(II). This type of nonenzymatic process can serve as a model for the biologically important enzymatic transphosphorylations that involve ATP, although... 

F) Preparation and Testing of Candidate Structures. Suitable candidate structures were then examined for relative efficacy in the mobilization of lead from lead-loaded mice. On the basis of previous studies in which we examined the relative ability of many compounds to remove cadmium from its aged deposits in the liver and the kidneys, six vicinal dithiols were selected, which were all monoesters of meso-2,3-dimercaptosuccinic acid. The compounds selected were the mono esters of meso- 2,3-dimercaptosuccinic acid with the following alcohols n-propyl, wo-propyl, n-butyl, wo-butyl, n-amyl, and iso-dmy (Figure 3). The results of experiments comparing these compounds showed that the n-butyl, iso-butyl, n-amyl, and isoamyl monoesters of m j<>-2,3-dimercaptosuccinic acid were the most effective compounds and that all were capable of reducing both kidney and brain lead levels in lead-intoxicated mice (45). The data collected on lead-intoxicated mice treated with the most effective of such compounds are compared with the results obtained with DMSA in Table I. 

Electron and x-ray diffraction studies of the morphology of monomer multilayers of vinyl stearate, (10), a-octadecyl acrylic acid (9), and the cadmium salt of the octadecyl monoester of funaric acid (11) indicate that these multilayers form first with an order-disorder hexagonal packing of the hydrocarbon chains, probably similar to the packing of the condensed monolayer at the air-water interface. 

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