Cacospongia

This compound also showed antispasmodic activity [122], A variety of cytotoxic compounds was isolated, including a bishomosesterterpene and dysidiolide from another Dysideci sp., a sulfated sesterterpene hydroquinone from a Hippospongia sp., and two new sesterterpenes, lintenolides F and G from the Caribbean sponge Cacospongia linteiformis [123,124],... 

Becerro, M. A., Paul, V. J., and Starmer, J., Intracolonial variation in chemical defenses of the sponge Cacospongia sp. and its consequences on generalist fish predators and the specialist nudibranch predator Glossodoris pallida, Mar. Ecol. Prog. Ser., 168, 187, 1998. 

Cimino, G., De Stefano, S., and Minale, L., Scalaradial, a third sesterterpene with the tetracarbocyclic skeleton of scalarin, from the sponge Cacospongia mollior, Experientia, 30, 846, 1974. 

Fijianolide B 6 (Scheme 6.1 Part 1) was first reported concurrently by two laboratories.42,43 Our group isolated fijianolides A and B from a sample of Cacospongia mycofijiensis, whereas the Scheuer group obtained identical compounds from an Indonesian sponge and its nudibranch predator,... 

Thereafter, several compounds closely related to ircinins and variabilin have been isolated [5,6]. Fusetani and co-workers [34] reported the isolation of two compounds, dehydroderivative of ircinin (8) and an isomer of variabilin (9) from the Japanese sponge Cacospongia scalaris. Both compounds inhibited the cell division of fertilised starfish eggs at a concentration of 1.0 pg/ml. This assay is a variation on the test with sea urchin embryos, which can detect DNA and RNA synthesis inhibitors, microtubule assembly and protein synthesis inhibitors, the common leads... 

From the Caribbean sponge Cacospongia linteiformis was isolated lintenone (156) with a new tricarbocyclic skeleton, which contains fused cyclohexane, cyclopentane and cyclobutane rings. Lintenone exhibited high antifeedant activity against the fish C. aurantus (30 pg per cm2 of food pellets), ichthyotoxicity to G. affinis (10 ppm) and moderate toxicity in A. salina assay (LC50 109 ppm) [166]. 

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