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CAAX protein prenylation GGTase

The first step of the series of modifications involved in the processing of CAAX-type prenyl proteins occurs in the cytoplasm, catalyzed by either protein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I (GGTase-I). The specificity for either of these two enzymes for the most part depends on the identity of the last amino acid X of the CAAX consensus sequence. When X is serine, cysteine, alanine, or glutamine, the 15 carbon farnesyl group is added to the cysteine catalyzed by FTase and when X is leucine, the 20 carbon geranylgeranyl group is added by... [Pg.260]

S, Q, A, or C, whereas GGTase-I recognizes CaaX boxes with X = L or F. Other prenylated proteins, such as the Rab proteins involved in vesicular transport, terminate in a CC, CXC, or CC(X) , 3 motif these proteins are substrates for protein geranylgeranyltransferase type II (GGTase-II) [3]. In order to be prenylated, Rab proteins must associate with Rab escort protein after geranylgeranylation, Rab escort protein delivers the prenylated Rab to membranes. [Pg.42]

See other pages where CAAX protein prenylation GGTase is mentioned: [Pg.3]    [Pg.7]    [Pg.72]    [Pg.118]    [Pg.119]    [Pg.261]    [Pg.262]    [Pg.262]    [Pg.41]    [Pg.42]    [Pg.159]    [Pg.692]    [Pg.692]    [Pg.693]    [Pg.534]    [Pg.139]    [Pg.275]    [Pg.692]    [Pg.692]    [Pg.693]    [Pg.4]    [Pg.46]    [Pg.94]    [Pg.107]    [Pg.113]    [Pg.143]    [Pg.143]    [Pg.1326]   
See also in sourсe #XX -- [ Pg.6 ]



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Prenyl

Prenylated proteins

Prenylation

Prenylations

Protein prenylation

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