Byakangelicin

Gonadotropin inhibition Byakangelicin (30) Interacted with sulfhydiyi group in pregnant mare s serum gon otropin, possibly through addition of protein -SH group to the 3,4-double bond of the coumarin [215,216]... 

It is possible that there are other proteins and enzymes that coumarins react with. As mentioned before they can react with thiol group of enzymes and hormones. In fact this has been shown in the case of byakangelicin that through its 3,4-double bond forms a 1,4-addition product with -SH group of HCG (human chorionic gonadotropin) [215,216]. 

Byakangelicin, B-80296 Fusarubin 0 -Et, in F-60108 Fusarubin ethyl acetal, in F-60108 Isobyakangelicolic acid, 1-80051... 

A crude aqueous extract of powdered Combretodendron africanum bark is a smooth muscle stimulant and reportedly has contraceptive as well as abortifacient properties. Another plant material with a fertility lowering effect on rats is byakangelicin, a furancoumarin from Ferula alliacea.3 A steroidal oily fraction extracted from the seed of Abius precatorius was orally active when tested for antifertility activity on rats and mice. The material also produced 80% sterility in rats when administered as a single oral dose of 150 mg of oil daily for 1-5 days in the post coital period. 

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